-胆烷酸
|
|
|
- CAS号:
- 1553-56-6
- 英文名:
- 3-Oxo-5beta-cholanoic Acid
- 英文别名:
- 3-oxocholanicacid;3-KETOCHOLANIC ACID;3-oxolithocholicacid;3-ketolithocholicacid;3-Oxo-5β-cholanic acid;5β-CHOLANIC acid-3-ONE;3-oxocholan-24-oic acid;5-B-CHOLANIC ACID-3-ONE;5β-Cholanic acid-3-one;3-Oxo-5β-cholanoic Acid
- 中文名:
- -胆烷酸
- 中文别名:
- -胆烷酸;脱氢石胆酸;3-氧代-5&Β;3-氧-5Β-胆酸;熊去氧胆酸杂质60;3-酮-5B-胆烷酸;化合物 T13502;3-氧代-5Β-胆酸;3-氧代-5Β-胆烷酸;3-氧代-5&BETA
- CBNumber:
- CB0675020
- 分子式:
- C24H38O3
- 分子量:
- 374.56
- MOL File:
- 1553-56-6.mol
|
|
|
-胆烷酸化学性质
-
熔点:
-
140-141 °C
-
|
-
沸点:
-
509.3±23.0 °C(Predicted)
-
|
-
密度:
-
1.069±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Refrigerator
-
|
-
溶解度:
-
Chloroform (Slightly), Methanol (Slightly)
-
|
-
形态:
-
Solid
-
|
-
酸度系数(pKa):
-
4.76±0.10(Predicted)
-
|
-
颜色:
-
White to Pale Yellow
-
|
-
CAS 数据库:
-
1553-56-6
-
|
-胆烷酸性质、用途与生产工艺
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid)，胆汁酸代谢产物，通过直接与关键转录因子RORγt (Kd=1.13 μM) 结合抑制 TH17 细胞分化。
Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity.
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells.
|
Animal Model:
|
B6 Jax mice (with a faecal slurry containing SFB)
|
|
Dosage:
|
0.3% (w/w)
|
|
Administration:
|
Gavaged; for 1 week
|
|
Result:
|
Significantly reduced the percentage of ileal TH17 cells.
|
-胆烷酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-125801 | 3-Oxo-5β-cholanoic acid | | 1 mg | 156元 |
| 2024/04/30 | HY-125801 | 3-Oxo-5β-cholanoic acid | | 5 mg | 312元 |
-胆烷酸
生产厂家
全球有 47家供应商
-胆烷酸国内生产厂家
1553-56-6, -胆烷酸 相关搜索:
- 药靶配体
- 熊去氧胆酸杂质60
- 3-氧-5Β-胆酸
- 3-酮-5B-胆烷酸(脱氢石胆酸)
- 3-酮-5B-胆烷酸
- 化合物 T13502
- 3-氧代-5Β-胆酸
- 3-恶唑烷-24-油酸
- 3-氧代-5BETA-胆酸
- 脱氢石胆酸
- 3-氧代-5Β-胆烷酸
- 3-氧代-5&BETA
- 3-氧代-5&Β
- -胆烷酸
- 1553-56-6
- Ursodeoxycholic acid impurity 60
- Cholan-24-oic acid, 3-oxo-, (5β)-
- cell,factor,RAR-related orphan receptor,3 Oxo 5β cholanoic acid,TH17,RORγt,differentiation,acid,bile,Inhibitor,responses,transcription,inhibit,ROR,3Oxo5βcholanoic acid,immune,3-oxoLCA
- 3-Oxo-5β-cholanoic Acid
- 5β-CHOLANIC acid-3-ONE
- 3-Oxo-5beta-cholanoic Acid
- DEHYDROLITHOCHOLIC ACID
- 3-oxo-5beta-cholanic acid
- 3-Keto-5β-cholanic acid
- 3-Oxo-5β-cholanoic Acid
- 3-Oxo-5β-cholanic acid
- 3-Oxo-5β-cholan-24-oic acid
- 5β-Cholanic acid-3-one
- 3-Keto-5β-cholanic acid, Dehydrolithocholic acid
- 3-oxocholan-24-oic acid
- 5-B-CHOLANIC ACID-3-ONE
- 3-oxolithocholicacid
- 3-oxocholanicacid
- 3-oxo-5-beta-cholan-24-oicacid
- 3-oxo-5-beta-cholan-24-oicaci
- 3-ketolithocholicacid
- (5-beta)-cholan-24-oicaci
- 3-KETO-5BETA-CHOLANIC ACID
- 3-KETOCHOLANIC ACID
- 5BETA-CHOLANIC ACID-3-ONE