O-(氯乙酰氨甲酰基)烟曲霉素醇
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- CAS号:
- 129298-91-5
- 英文名:
- AGM-1470
- 英文别名:
- Tnp-470;AGM-1470;NSC642492;TNP470,TNP 470;Fumagillin Impurity 1;O-Chloracetyl-carbamoyl fumagillol;O-(chloroacetylcarbamoyl)fumagillol;6-O-chloroacetylcarbamoylfumagillol;TNP-470 - CAS 129298-91-5 - Calbiochem;O-(chloroacetyl-carbaMoyl) fuMagillol,TNP-470
- 中文名:
- O-(氯乙酰氨甲酰基)烟曲霉素醇
- 中文别名:
- 夫马菌素醇;烟曲霉素杂质1;化合物 T17110;O-(氯乙酰氨甲酰基)烟曲霉素醇;TNP-470 CALBIOCHEM;甲硫氨酸氨肽酶-2抑制剂(TNP-470);TNP 470/O-(氯乙酰氨甲酰基)烟曲霉素醇;[(3R,4S,5S,6R)-5-甲氧基-4-[(2R,3R)-2-甲基-3-(3-甲基丁-2-烯基)环氧乙烷-2-基]-1-氧杂螺[2.5]辛烷-6-醇] N-(2-氯乙酰基)氨基甲酸酯
- CBNumber:
- CB11251062
- 分子式:
- C19H28ClNO6
- 分子量:
- 401.88
- MOL File:
- 129298-91-5.mol
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O-(氯乙酰氨甲酰基)烟曲霉素醇化学性质
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熔点:
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90-93°C
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比旋光度:
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D24 -46.6° (c = 0.44 in CHCl3)
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密度:
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1.26±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: >15mg/mL
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酸度系数(pKa):
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7.19±0.46(Predicted)
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形态:
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White to light yellow solid
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颜色:
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White to Pale Yellow Waxy
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稳定性:
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Hygroscopic
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O-(氯乙酰氨甲酰基)烟曲霉素醇性质、用途与生产工艺
TNP-470 是甲硫氨酸氨肽酶-2 抑制剂，也是一种血管生成抑制剂。
methionine aminopeptidase-2, angiogenesis
No significant difference of apoptotic cell numbers is observed between cells treated with TNP-470 and the controls. The IC
50
s of TNP-470 are 16.86±0.9 µg/mL, 3.16±0.6 µg/mL and 1.78±0.8 µg/mL for KKU-M213 cells at 24, 48 and 72 h, respectively. The results show that TNP-470 significantly reduces the number of migrated cells and invaded cells as compare with the vehicle treated group. TNP-470 decreases the migrated cells of KKU-M213 to 26% and of KKU-M214 to 11% (P<0.01). Similarly, TNP-470 also significantly affects cell invasion, the number of invaded cells is reduced to 25% in KKU-M213 (P<0.01) and to 15% in KKU-M214 (P<0.01). The relative expressions of
MMP2
,
MMP9
and
c-MYC
in TNP-470 treated cells are significantly suppressed compare to the vehicle treated cells.
Treatment with TNP-470 attenuates (P<0.05) liver lipid accumulation compare to high fat fed (HFF) mice. By day 5, TNP-470 treated mice consume significantly less grams of high fat food than vehicle treated HFF mice. By day 15 of treatment, TNP-470 mice are consuming an equivalent number of calories to that of chow fed mice, despite the provision of high fat diet. Treatment with TNP-470 increases (P<0.05) expression of adipose tissue LPL mRNA, compare to chow-fed and high-fat fed controls. TNP-470 decreases energy intake and increases energy expenditure.
O-(氯乙酰氨甲酰基)烟曲霉素醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101932 | O-(氯乙酰氨甲酰基)烟曲霉素醇
TNP-470 | 129298-91-5 | 1 mg | 2800元 |
| 2024/01/25 | HY-101932 | O-(氯乙酰氨甲酰基)烟曲霉素醇
TNP-470 | 129298-91-5 | 5mg | 7900元 |
129298-91-5, O-(氯乙酰氨甲酰基)烟曲霉素醇 相关搜索:
- 细胞生物学试剂
- C19H28CINO6
- 烟曲霉素杂质1
- TNP-470 CALBIOCHEM
- 化合物 T17110
- 夫马菌素醇
- 甲硫氨酸氨肽酶-2抑制剂(TNP-470)
- [(3R,4S,5S,6R)-5-甲氧基-4-[(2R,3R)-2-甲基-3-(3-甲基丁-2-烯基)环氧乙烷-2-基]-1-氧杂螺[2.5]辛烷-6-醇] N-(2-氯乙酰基)氨基甲酸酯
- O-(氯乙酰氨甲酰基)烟曲霉素醇
- TNP 470/O-(氯乙酰氨甲酰基)烟曲霉素醇
- 129298-91-5
- Fumagillin Impurity 1
- TNP470,TNP 470
- 6-O-chloroacetylcarbamoylfumagillol
- TNP-470 - CAS 129298-91-5 - Calbiochem
- Carbamic acid, N-(2-chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
- (3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2
- O-Chloracetyl-carbamoyl fumagillol
- (Chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
- O-(chloroacetyl-carbaMoyl) fuMagillol,TNP-470
- N-(2-Chloroacetyl)carbamicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester
- Tnp-470
- Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
- AGM-1470
- [(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate
- O-(CHLOROACETYLCARBAMOYL)FUMAGILLOLTNP-470 AGM-1470
- O-(chloroacetylcarbamoyl)fumagillol
- NSC642492