BDP5290
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- CAS号:
- 1817698-21-7
- 英文名:
- BDP5290
- 英文别名:
- BDP5290;BDP5290;BDP-5290;BDP 5290;4-Chloro-1-(4-piperidyl)-N-[5-(2-pyridyl)-1H-pyrazol-4-yl]pyrazole-3-carboxamide;1H-Pyrazole-3-carboxamide, 4-chloro-1-(4-piperidinyl)-N-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-;inhibit,Rho-kinase,Rho-associated kinase,BDP-5290,BDP5290,Rho-associated protein kinase,ROK,BDP 5290,Inhibitor,ROCK
- 中文名:
- BDP5290
- 中文别名:
- 化合物BDP5290;ROCK和MRCK抑制剂(BDP5290)
- CBNumber:
- CB13362364
- 分子式:
- C17H18ClN7O
- 分子量:
- 371.82
- MOL File:
- 1817698-21-7.mol
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BDP5290化学性质
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沸点:
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584.0±50.0 °C(Predicted)
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密度:
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1.56±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 12.5 mg/mL (33.62 mM)
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酸度系数(pKa):
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10.83±0.50(Predicted)
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BDP5290性质、用途与生产工艺
BDP5290 是 ROCK 和 MRCK 的有效抑制剂，对于 ROCK1，ROCK2，MRCKα 和 MRCKβ 的 IC50 值分别为 5 nM，50 nM，10 nM 和 100 nM。
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ROCK1
5 nM (IC
50
)
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ROCK2
50 nM (IC
50
)
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MRCKα
10 nM (IC
50
)
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MRCKβ
100 nM (IC
50
)
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The K
i
of BDP5290 for MRCKα is 10 nM, which is slightly more than the K
i
of 4 nM for MRCKβ. 3 μM BDP5290 completely inhibits myosin II light chain (MLC) phosphorylation induced by MRCKβ, but not by ROCK1 or ROCK2. At higher concentrations, BDP5290 reduces MLC phosphorylation (pMLC) to undetectable levels. BDP5290 reduces MDA-MB-231 invasion at all tested concentrations starting from 0.1 μM, with virtually complete inhibition at 10 μM. After 24 hours in the presence of BDP5290 cell viability is slightly reduced with an EC
50
>10 μM. Wound closure is inhibited by >60% at 1 μM BDP5290, a concentration that has no effect on cell viability.
BDP5290
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12437 | BDP5290 | | 1 mg | 681元 |
| 2024/04/30 | HY-12437 | BDP5290
BDP5290 | 1817698-21-7 | 5mg | 1500元 |
1817698-21-7, BDP5290 相关搜索:
- 药靶配体
- 细胞生物学试剂
- 817698-21-7
- ROCK和MRCK抑制剂(BDP5290)
- 化合物BDP5290
- 1817698-21-7
- inhibit,Rho-kinase,Rho-associated kinase,BDP-5290,BDP5290,Rho-associated protein kinase,ROK,BDP 5290,Inhibitor,ROCK
- 4-Chloro-1-(4-piperidyl)-N-[5-(2-pyridyl)-1H-pyrazol-4-yl]pyrazole-3-carboxamide
- BDP5290
- BDP5290;BDP-5290;BDP 5290
- 1H-Pyrazole-3-carboxamide, 4-chloro-1-(4-piperidinyl)-N-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-