BDP5290
| 中文名称 | BDP5290 |
|---|---|
| 中文同义词 | 化合物BDP5290;ROCK和MRCK抑制剂(BDP5290) |
| 英文名称 | BDP5290 |
| 英文同义词 | 1H-Pyrazole-3-carboxamide, 4-chloro-1-(4-piperidinyl)-N-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-;BDP5290;BDP-5290;BDP 5290;BDP5290;4-Chloro-1-(4-piperidyl)-N-[5-(2-pyridyl)-1H-pyrazol-4-yl]pyrazole-3-carboxamide;inhibit,Rho-kinase,Rho-associated kinase,BDP-5290,BDP5290,Rho-associated protein kinase,ROK,BDP 5290,Inhibitor,ROCK |
| CAS号 | 1817698-21-7 |
| 分子式 | C17H18ClN7O |
| 分子量 | 371.82 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 1817698-21-7.mol |
| 结构式 |  |
BDP5290 性质
| 沸点 | 584.0±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.56±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：12.5 mg/mL（33.62 mM） |
| 酸度系数(pKa) | 10.83±0.50(Predicted) |
|
ROCK1 5 nM (IC 50 ) |
ROCK2 50 nM (IC 50 ) |
MRCKα 10 nM (IC 50 ) |
MRCKβ 100 nM (IC 50 ) |
The K i of BDP5290 for MRCKα is 10 nM, which is slightly more than the K i of 4 nM for MRCKβ. 3 μM BDP5290 completely inhibits myosin II light chain (MLC) phosphorylation induced by MRCKβ, but not by ROCK1 or ROCK2. At higher concentrations, BDP5290 reduces MLC phosphorylation (pMLC) to undetectable levels. BDP5290 reduces MDA-MB-231 invasion at all tested concentrations starting from 0.1 μM, with virtually complete inhibition at 10 μM. After 24 hours in the presence of BDP5290 cell viability is slightly reduced with an EC 50 >10 μM. Wound closure is inhibited by >60% at 1 μM BDP5290, a concentration that has no effect on cell viability.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-12437 | BDP5290 | 1 mg | 681元 | |
| 2024/04/30 | HY-12437 | BDP5290 BDP5290 | 1817698-21-7 | 5mg | 1500元 |