氧托溴铵
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- CAS号:
- 30286-75-0
- 英文名:
- OXITROPIUM BROMIDE
- 英文别名:
- Ba 253;ba253br;Oxivent;Ventilat;Tersigan;tersigat;oxitropium;ba-253-br-l;Oxitropiumbromid;oxitropiobromuro
- 中文名:
- 氧托溴铵
- 中文别名:
- 氧托溴铵;溴化氧托溴铵;化合物 T16417;氧托溴铵 EP标准品
- CBNumber:
- CB1727939
- 分子式:
- C19H26BrNO4
- 分子量:
- 412.32
- MOL File:
- 30286-75-0.mol
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氧托溴铵化学性质
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熔点:
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203-204° (dec)
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比旋光度:
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D21 -25° (c = 2.0 in water)
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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Very soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
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颜色:
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Off-White to Pale Yellow
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稳定性:
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Hygroscopic
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氧托溴铵性质、用途与生产工艺
Oxitropium bromide 是毒蕈碱受体拮抗剂。Oxitropium bromide 具有抗胆碱能支气管扩张作用，能用于哮喘和慢性阻塞性肺疾病的研究。
Oxitropium bromide is a muscarinic antagonist which blocks musucarinic acetylcholine receptors (mAChR). Incubation with oxitropium bromide of untreated diaphragm muscle and diaphragm muscle injected with endotoxin does not increase the force-frequency curves dose-dependently
in vitro
; however, it causes both types of muscle to be fatigue resistant.
Oxitropium bromide inhalation shifts force-frequency curves upward at 2 h after inhalation and inhibits the decrease of force-frequency curves due to endotoxin injection
in vivo
. Oxitropium bromide strongly and persistently inhibits the acetylcholine (ACh)-induced resistance. The increase in resistance induced by histamine, serotonin, leukotriene D4 or antigen is prevented by oxitropium bromide oxitropium bromide. Inhalation of the anticholinergic agent oxitropium bromide at doses of 1.5 μg and higher greatly attenuates the decrease in mucus score produced by intravenous histamine but not by inhaled histamine.
氧托溴铵
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氧托溴铵
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30286-75-0, 氧托溴铵 相关搜索:
- C19H26BrNO4
- C19H26NO4Br
- 化合物 T16417
- 溴化氧托溴铵
- 氧托溴铵 EP标准品
- 氧托溴铵
- 30286-75-0
- (1R,2R,4S,5S,7s,9R)-9-ethyl-7-(((S)-3-hydroxy-2-phenylpropanoyl)oxy)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide
- Oxitropium bromide CRS
- N-Ethylscopolammonium bromide (6CI, 7CI)
- N-Ethylnorscopolamine-methyl bromide
- N-Ethylnorscopolamine methylbromide
- Hyoscine ethobromide
- Ba 253
- 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 9-ethyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide, (1a,2b,4b,5a,7b)- (9CI)
- 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 9-ethyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, bromide, [7(S)-(1a,2b,4b,5a,7b)]-
- tersigat
- oxytropiumbromide
- oxitropium
- oxitropiobromuro
- n-ethyl-norscopolaminemethobromide
- enylpropoxy)-9-methyl-,bromide,(7(s)-(1-alpha,2-beta,4-beta,5-alpha,7-beta))
- OXITROPIUM BROMIDE
- N-Ethylnorscopolammonium bromide
- Oxitropiumbromid
- Ventilat
- Tersigan
- Scopolamine ethobromide
- Oxivent
- bromurodeoxitropio
- ba-253-br-l
- ba253br
- 3-oxa-9-azoniatricyclo(3.3.1.0(sup2,4))nonane,9-ethyl-7-(3-hydroxy-1-oxo-2-ph
- (-)-n-ethyl-norhyoscine-methobromide