马来酸三甲丙咪嗪
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- CAS号:
- 521-78-8
- 英文名:
- TRIMIPRAMINE MALEATE SALT
- 英文别名:
- TRIMIPRAMINE MALEATE;Trimipramina;surmontilmaleate;Einecs 208-318-3;trimepriminemaleate;TRIMIPRAMINEMALEATE,BP;Trimeprimine Monomaleat;trimipramineacidmaleate;trimepriminemonomaleate;Trimipramine maleate CRS
- 中文名:
- 马来酸三甲丙咪嗪
- 中文别名:
- 马来酸曲米帕明盐;马来酸三米普拉明;曲米帕明马来酸盐;马来酸三甲丙咪嗪;三甲丙咪嗪马来酸盐;马来酸三甲丙咪嗪 EP标准品;马来酸曲米帕明 USP标准品;三甲丙咪嗪为峰鉴别 EP标准品;TRIMIPRAMINE MALEATE[干冰运输];3-(10,11-二氢-5H-二苯并[B,F]氮杂卓-5-基)-N,N,2-三甲基丙烷-1-胺马来酸盐
- CBNumber:
- CB3104538
- 分子式:
- C24H30N2O4
- 分子量:
- 410.51
- MOL File:
- 521-78-8.mol
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马来酸三甲丙咪嗪化学性质
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熔点:
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141-143°C
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闪点:
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11 °C
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储存条件:
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2-8°C
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溶解度:
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chloroform: soluble50 mg/ml, clear, colorless to faintly yellow
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形态:
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powder
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颜色:
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white
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EPA化学物质信息:
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Trimipramine maleate (521-78-8)
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马来酸三甲丙咪嗪性质、用途与生产工艺
Trimipramine maleate 是 5-HT 受体的拮抗剂，其对 5-HT1C，5-HT2 和 5-HT1A 受体的 pKi 值分别为 6.39，8.10，4.66。
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5-HT
1C
Receptor
6.39 (pKi)
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5-HT
2
Receptor
8.10 (pKi)
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sPLA2
4.66 (pKi)
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Trimipramine displays much higher affinity for 5-HT
2
than for 5-HT
1C
receptors.
The chronic administration of Trimipramine (5 mg/kg/day), as delivered by the osmotic minipump in 14 days produce significant increases in the regional concentration of 5-HT. The increases are highest in the frontal cortex and the hippocampus, followed by the olfactory tubercles and the hypothalamus. The Trimipramine treatment also produces marked increases in brain 5-HIAA concentrations ranging from 63% in the hippocampus to 25% in the nucleus accumbens with intermediate values for the hypothalamus, olfactory tubercles, frontal cortex and nucleus accumbens. Trimipramine treatment produces significant increases in DA concentrations in the nucleus accumbens, striaturn, and olfactory tubercles reaching 43, 21 and 11% respectively. Chronic administration of Trimipramine produces a marked reduction in the number of frontal cortex 5-HT
2
and striatal DA D
2
receptors. The chronic administration of Trimipramine produces an increase in the brain regional level of monoamines and metabolites indicating a greater synthesis rate for DA and 5-HT coinciding with an adaptive down regulation of 5-HT
2
and DA D
2
receptors.
马来酸三甲丙咪嗪
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-B1213 | 马来酸三甲丙咪嗪
Trimipramine maleate | 521-78-8 | 100mg | 500元 |
| 2024/04/30 | HY-B1213 | 马来酸三甲丙咪嗪
Trimipramine maleate | 521-78-8 | 10mM * 1mLin DMSO | 550元 |
马来酸三甲丙咪嗪
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马来酸三甲丙咪嗪国内生产厂家
521-78-8, 马来酸三甲丙咪嗪 相关搜索:
- Neurotransmitters
- Neurotransmission (Obesity)
- Neurotransmission
- Biogenic Amine Transport InhibitorsObesity Research
- Biogenic Amine Transport Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Amines
- 药靶配体
- 标准品
- 医药原料
- 小分子抑制剂
- C20H26N2C4H4O4
- 马来酸曲米帕明盐
- 3-(10,11-二氢-5H-二苯并[B,F]氮杂卓-5-基)-N,N,2-三甲基丙烷-1-胺马来酸盐
- 三甲丙咪嗪马来酸盐
- 马来酸三米普拉明
- TRIMIPRAMINE MALEATE[干冰运输]
- 马来酸三甲丙咪嗪 EP标准品
- 马来酸曲米帕明 USP标准品
- 三甲丙咪嗪为峰鉴别 EP标准品
- 曲米帕明马来酸盐
- 马来酸三甲丙咪嗪
- 521-78-8
- hOCT3,hNAT,dopamine,5-HTIA receptors,neurological disease,serotonin,5-HT1A,5-hydroxytryptamine,5-HT,Inhibitor,antidepressants,5-hydroxytryptamine Receptor,Serotonin Receptor,Bacterial,hOCT1,5-HT1C,hDAT,Trimipramine,Trimipramine maleate,inhibit,5-HT2,hSERT,noradrenaline,human organic cation transporters,anxiolytic,DA D2 receptor,5-HTlc receptors,5-HT Receptor,hOCT2
- TRIMIPRAMINE MALEATE
- 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine maleate
- Trimipramine Maleate (1692709)
- Trimipramine maleateQ: What is
Trimipramine maleate Q: What is the CAS Number of
Trimipramine maleate Q: What is the storage condition of
Trimipramine maleate Q: What are the applications of
Trimipramine maleate
- (2RS)-3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2- trimethylpropan-1-amine (Z)-butenedioate
- Trimipramine for peak identification CRS
- Trimipramine maleate CRS
- Trimipramine maleate salt solution
- Trimipramine Maleate (100 mg)
- Einecs 208-318-3
- 5H-Dibenz(B,F)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (Z)-2-butenedioate (1:1)
- 5H-Dibenz(B,F)azepine, 10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-, maleate (1:1)
- Trimipramine solution maleate salt
- 10,11-Dihydro-N,N,-trimethyl-5H-dibenz[b,f]azepine-5-propanamine (2Z)-2-butenedioate
- 5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-, maleate (1:1) (8CI)
- TRIMIPRAMINEMALEATE,BP
- 5H-Dibenzb,fazepine-5-propanamine, 10,11-dihydro-N,N,.beta.-trimethyl-, (2Z)-2-butenedioate (1:1)
- Trimipramina
- Trimeprimine Monomaleat
- 10,11-Dihydro-N,N,b-trimethyl-5H-dibenz[b,f]azepine-5-propanamine (2Z)-2-butenedioate
- TRIMIPRAMINE MALEATE METHANOL SOLUTION
- trimipramine hydrogen maleate
- trimipramineacidmaleate
- trimepriminemonomaleate
- trimepriminemaleate
- surmontilmaleate
- f)azepine,10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-5h-dibenz(mal
- TRIMIPRAMINE MALEATE SALT