密朗丁
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- CAS号:
- 86-34-0
- 英文名:
- PHENSUXIMIDE
- 英文别名:
- pm334;Lifen;Epimid;Lifene;PM 334;Epimal;Mirotin;Milontin;Milonton;Mirontin
- 中文名:
- 密朗丁
- 中文别名:
- 密朗丁;米浪丁;苯琥胺;化合物 T25945;苯琥胺 USP标准品;1-甲基-3-苯基-2,5-吡咯烷二酮;1-甲基-3-苯基吡咯烷-2,5-二酮
- CBNumber:
- CB3480203
- 分子式:
- C11H11NO2
- 分子量:
- 189.21
- MOL File:
- 86-34-0.mol
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密朗丁化学性质
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熔点:
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71-73°
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沸点:
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324.47°C (rough estimate)
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密度:
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1.1596 (rough estimate)
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折射率:
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1.5012 (estimate)
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储存条件:
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Refrigerator
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溶解度:
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Chloroform (Slightly), Ethyl Acetate (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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-1.86±0.40(Predicted)
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颜色:
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White to Off-White
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水溶解性:
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4.2g/L(25 ºC)
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密朗丁性质、用途与生产工艺
Phensuximide 是一种琥珀酰亚胺类抗癫痫 (antiepileptic) 和抗惊厥 (anticonvulsant) 试剂。Phensuximide 可以抑制去极化脑组织中 cyclic AMP 和 cyclic GMP 的积累。在动物模型中，Phensuximide 可用于癫痫研究的相关研究。
IC50: cyclic AMP and cyclic GMP accumulation
Phensuximide produce depolarization-induced accumulation of cyclic GMP or cyclic AMP levels with ID
50
values of 8.00 mM or 6.20 mM in incubated slices of mouse cerebral cortex.Phensuximide (0.5-2.0 mM) has the ability to competitively inhibit mephenytoin 4-hydroxylase activity in human liver microsomes, the K
i
and K
m
values are 559 μM and 235 μM, respectively.
Phensuximide (intraperitoneal injection; 1.25 mmol/kg; single dose) induces mild changes in renal function, including: trace hematuria, increased proteinuria and decreased paminohippurate uptake in Sprague-Dawley rats.Phensuximide (intraperitoneal injection; 0.3 or 0.6 mmol/kg; 5-7 days) results in transient hematuria and proteinuria, but no change in the other renal function parameters studied. It is concluded that phensuximide produces mild, transient renal effects in Fischer 344 rats, and that the Fischer 344 rat is a suitable model for studying phensuximide-induced toxicity to the urinary tract.
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Animal Model:
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Fischer 344 rats
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Dosage:
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0.3 or 0.6 mmol/kg
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Administration:
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Intraperitoneal injection; 5-7 days
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Result:
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Induced urotoxicity following daily administration for 5-7 days in Fischer 344 rats.
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密朗丁
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-B1730 | Phensuximide | | 5 mg | 687元 |
| 2024/01/25 | HY-B1730 | 密朗丁
Phensuximide | 86-34-0 | 10mg | 1100元 |
密朗丁
生产厂家
全球有 53家供应商
密朗丁国内生产厂家
86-34-0, 密朗丁 相关搜索:
- MILONTIN
- 高端化学
- 化合物 T25945
- 苯琥胺 USP标准品
- 1-甲基-3-苯基-2,5-吡咯烷二酮
- 密朗丁
- 米浪丁
- 苯琥胺
- 1-甲基-3-苯基吡咯烷-2,5-二酮
- 86-34-0
- RSYY PHENSUXIMIDE
- AI3-20372
- AI320372
- AI3 20372
- Phensuximide (1528002)
- PHENSUXIMIDE USP/EP/BP
- 1-methyl-3-phenylpyrrolidine-2,5-dione
- 1-methyl-3-phenyl-pyrrolidine-2,5-dione
- 5-(Diallylaminomethyl)-3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone
- Succitmal
- Lifen
- Epimal
- PHENSUXIMIDE
- Succitimal
- Succinimide, N-methyl-2-phenyl-
- pm334
- PM 334
- Phenylsuximide
- Phensuximid
- Phenosuccimide
- N-Methyl-alpha-phenylsuccinimide
- N-Methyl-alpha-phenolsuccinimide
- n-methyl-2-phenyl-succinimide
- N-Methyl-2-phenylsuccinimide
- n-methyl-2-phenyl-succinimid
- Mirotin
- Mirontin
- Milonton
- Milontin
- Methylphenylsuccinimide
- Lifene
- Fenosuccimide
- Epimid
- 2,5-Pyrrolidinedione, 1-methyl-3-phenyl-
- 1-Methyl-3-Phenylsuccinimide
- PHENSUCCIMIDE
- Phensuximide (500 mg)
- 1-methyl-3-phenyl-pyrrolidine-2,5-quinone
- 1-Methyl-3-phenylpyrrolidin-2,5-dione
- 1-methyl-3-phenyl-5-pyrrolidinedione
- 1-Methyl-3-phenyl-2,5-pyrrolidinedione
- (.+/-.)-N-Methyl-2-phenylsuccinimide