乙氢去甲奎宁
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- CAS号:
- 522-60-1
- 英文名:
- ETHYLHYDROCUPREINE
- 英文别名:
- optochin;numoquin;optoquine;Optochine;Numoquine;Ethylhydrocuprein;ETHYLHYDROCUPREINE;hydrocupreineethylether;Hydrocupureine ethyl ether;6’-ethoxy-hydrocinchonidin
- 中文名:
- 乙氢去甲奎宁
- 中文别名:
- 乙氢去甲奎宁;乙基氢化脱甲奎宁;乙基氢化铜色树碱;乙基氢化铜色金鸡纳碱
- CBNumber:
- CB4490364
- 分子式:
- C21H28N2O2
- 分子量:
- 340.46
- MOL File:
- 522-60-1.mol
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乙氢去甲奎宁化学性质
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熔点:
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123-128° when solvent-free
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比旋光度:
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D25 -136.2° (alcohol)
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沸点:
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476.25°C (rough estimate)
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密度:
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1.1027 (rough estimate)
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折射率:
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1.6180 (estimate)
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储存条件:
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2-8°C
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乙氢去甲奎宁性质、用途与生产工艺
Ethylhydrocupreine (Optochin) 是一种具有抗菌作用的奎宁衍生物，具有抗肺炎链球菌 (S. pneumoniae) 的活性。Ethylhydrocupreine 还具有抗 Plasmodium falciparum 的抗疟活性，IC50 为 25.75 nM。Ethylhydrocupreine 是一种 Gallus gallus 2 受体 (ggTas2r1，ggTas2r2 和 ggTas2r7) 激动剂。
S. pneumoniae
IC50: 25.75 nM (
Plasmodium falciparum
)
ggTas2r1,
ggTas2r2 and ggTas2r7
The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated
S. pneumoniae
strains (
S. pneumoniae
D39 NCTC 7466,
S. pneumoniae
R6 ATCC BAA-255 and
S. pneumoniae
ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied.
The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs.
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522-60-1, 乙氢去甲奎宁 相关搜索:
- Miscellaneous
- 药靶配体
- 乙氢去甲奎宁
- Analytical Chromatography Product Catalog
- Alphabetic
- Analytical Standards
- EQ - EZ
- C21H28N2O2
- 乙基氢化铜色树碱
- 乙基氢化铜色金鸡纳碱
- 乙基氢化脱甲奎宁
- 乙氢去甲奎宁
- 522-60-1
- Cinchonan-9-ol, 6'-ethoxy-10,11-dihydro-, (8α,9R)-
- ETHYLHYDROCUPREINE
- o(sup6’)-ethyl-hydrocuprein
- numoquin
- hydrocupreineethylether
- 6’-ethoxy-hydrocinchonidin
- 6’-ethoxy-10,11-dihydro-,(8-alpha,9r)-cinchonan-9-o
- Cinchonan-9-ol,6'-ethoxy-10,11-dihydro-, (8a,9R)-
- Hydrocupureine ethyl ether
- Ethylhydrocuprein
- Optochine
- Numoquine
- ethylhydrocupreine free base*crystalline
- optoquine
- optochin