101189-47-3
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- CAS号:
- 101189-47-3
- 英文名:
- 2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole
- 英文别名:
- CP-66,948;CP66948,CP 66948;2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole;Guanidine, N-[4-(2-methyl-1H-imidazol-5-yl)-2-thiazolyl]-N'-pentyl-;1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine
- 中文名:
- 101189-47-3
- 中文别名:
- 化合物 T15005
- CBNumber:
- CB51240303
- 分子式:
- C13H20N6S
- 分子量:
- 292.4
- MOL File:
- 101189-47-3.mol
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101189-47-3化学性质
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沸点:
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517.0±42.0 °C(Predicted)
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密度:
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1.34±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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11.38±0.10(Predicted)
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101189-47-3性质、用途与生产工艺
CP-66948 是 histamine H2 受体拮抗剂，能够抑制胃酸分泌，保护粘膜的作用。
The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED
50
value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED
50
values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED
50
values of 12 mg/kg per os and 6 mg/kg subcutaneously).
101189-47-3
上下游产品信息
上游原料
下游产品
101189-47-3, 101189-47-3 相关搜索:
- 化合物 T15005
- 101189-47-3
- CP66948,CP 66948
- Guanidine, N-[4-(2-methyl-1H-imidazol-5-yl)-2-thiazolyl]-N'-pentyl-
- 1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine
- CP-66,948
- 2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole