101189-47-3
| 中文名称 | 101189-47-3 |
|---|---|
| 中文同义词 | 化合物 T15005 |
| 英文名称 | 2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole |
| 英文同义词 | 2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole;CP-66,948;1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine;Guanidine, N-[4-(2-methyl-1H-imidazol-5-yl)-2-thiazolyl]-N'-pentyl-;CP66948,CP 66948 |
| CAS号 | 101189-47-3 |
| 分子式 | C13H20N6S |
| 分子量 | 292.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 101189-47-3.mol |
| 结构式 |  |
101189-47-3 性质
| 沸点 | 517.0±42.0 °C(Predicted) |
|---|---|
| 密度 | 1.34±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 11.38±0.10(Predicted) |
CP-66948 是 histamine H2 受体拮抗剂，能够抑制胃酸分泌，保护粘膜的作用。
The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED 50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED 50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED 50 values of 12 mg/kg per os and 6 mg/kg subcutaneously).