B-赤霉醇
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- CAS号:
- 42422-68-4
- 英文名:
- BETA-ZEARALANOL
- 英文别名:
- P-1560;taleranol;β-Zeranol;BETAZERANOL;B-zearalanol;β-Zearalanol;BETA-ZEARALANOL;Zearalanol, beta-;P-1560【pharmaceutical】;β-Zearalanol,β-Zeranol
- 中文名:
- B-赤霉醇
- 中文别名:
- B-赤霉醇;Β-玉米赤霉醇;化合物 T14548;BETA-玉米赤霉醇;-ZEARALANOL;玉米赤霉醇(Β-玉米赤霉醇)
- CBNumber:
- CB5142969
- 分子式:
- C18H26O5
- 分子量:
- 322.4
- MOL File:
- 42422-68-4.mol
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B-赤霉醇化学性质
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熔点:
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134-137°C
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沸点:
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576.0±50.0 °C(Predicted)
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密度:
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1.153±0.06 g/cm3(Predicted)
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闪点:
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2℃
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储存条件:
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2-8°C
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溶解度:
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Methanol: 10 mg/ml
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形态:
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A solid
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酸度系数(pKa):
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8.08±0.60(Predicted)
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BRN:
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4844761
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B-赤霉醇性质、用途与生产工艺
Beta-Zearalanol 是由镰刀菌属 Fusarium 产生的一种霉菌毒素，可以在哺乳动物生殖细胞中引起细胞凋亡 (apoptosis) 和氧化应激反应。 Beta-Zearalanol 是玉米赤霉烯酮（ZEA）的衍生物，可以与葡萄糖醛酸 (glucuronic acid) 结合。
βeta-Zearalenol (0-200 μM; 24 hours) inhibits BGC proliferation in a dose-dependent manner, with an IC
50
of 25 μM.
βeta-Zearalenol (0-100 μM; 72 hours) shows high toxic with an IC
50
of 15.2 μM in the HepG2 cells, synergistic effect of β-ZOL+ZEN or β-ZOL+α-ZOL with IC
50
values of 19.8 uM, 16.8 uM, respectively.
βeta-Zearalenol (0-10 μM; 72 hours) has the highest inhibition effect on the all three investigated cytokines: IL-8, IL-1β and TNF-α by comparation with ZEA or α-Zearalenol.
Cell Viability Assay
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Cell Line:
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HepG2 cells
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Concentration:
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0-100 μM
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Incubation Time:
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72 hours
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Result:
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Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol.
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Cell Proliferation Assay
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Cell Line:
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BGC cells
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Concentration:
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0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM
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Incubation Time:
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24 hours
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Result:
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Inhibited cell proliferation in a dose-dependent manner.
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RT-PCR
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Cell Line:
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HepG2 cells
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Concentration:
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1 μM, 5 μM, 10 μM
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Incubation Time:
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72 hours
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Result:
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Had the higher cytotoxic effect in comparation with α-Zearalenol.
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B-赤霉醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-N6740 | Beta-Zearalanol | | 10 mM * 1 mLin DMSO | 1760元 |
| 2024/01/25 | HY-N6740 | B-赤霉醇
Beta-Zearalanol | 42422-68-4 | 5mg | 1600元 |
B-赤霉醇
生产厂家
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B-赤霉醇国内生产厂家
42422-68-4, B-赤霉醇 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Chiral Reagents
- Aromatics
- Heterpocycles
- 抑制剂
- 医药原料
- 霉菌毒素类
- 微生物代谢物
- 玉米赤霉醇(Β-玉米赤霉醇)
- 化合物 T14548
- BETA-玉米赤霉醇
- Β-玉米赤霉醇
- -ZEARALANOL
- B-赤霉醇
- 42422-68-4
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Taleranol D4 Q: What is the CAS Number of
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- BETA-ZEARALANOL
- taleranol