9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物
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- CAS号:
- 206658-92-6
- 英文名:
- 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+%
- 英文别名:
- Tacrine HCl hydrate;9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+%;Cholinesterase (ChE),inhibit,Tacrine hydrochloride (hydrate),Inhibitor
- 中文名:
- 9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物
- 中文别名:
- 他克林盐酸盐;盐酸他克林水合物;他克林盐酸盐水合物;他克林盐酸盐一水合物;THA 盐酸盐 水合物;单满吖啶氨 盐酸盐 水合物;4-四氢吖啶 盐酸盐 水合物
- CBNumber:
- CB5548129
- 分子式:
- C13H17ClN2O
- 分子量:
- 252.74
- MOL File:
- Mol file
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9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物化学性质
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熔点:
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284-286°C (lit.)
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储存条件:
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Store at -20°C
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溶解度:
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H2O: soluble
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形态:
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powder
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颜色:
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faint yellow
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9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物性质、用途与生产工艺
Tacrine (Tetrahydroaminacrine, Tetrahydroaminoacridine) 是胆碱酯酶(cholinesterase)抑制剂,可对抗骨骼肌松弛药的作用,可作为呼吸兴奋剂并用于治疗阿兹海默病和其他中枢神经系统障碍。它也是组胺N-甲基转移酶(histamine N-methyltransferase)抑制剂。
Target | Value |
HNMT
()
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cholinesterase
()
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Tacrine hydrochloride hydrate (12.5 to 37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner. The IC
50
is 31 nM for snake venom AChE and 25.6 nM for human BChE.
Pretreatment with Tacrine hydrochloride hydrate also modifies absolute levels of cocaine self-administration during reacquisition. Body weight declines approximately one-half percent over four days of treatment with intravenous Tacrine hydrochloride hydrate. Delivery of Tacrine hydrochloride hydrate by osmotic pump does not alter either linear- or repeated- cocaine-induced locomotor activity. There is no significant main effect or interaction with Tacrine hydrochloride hydrate treatment on active lever responding during reinstatement. Post hoc comparisons indicate that rats self-administering cocaine has significantly lower alkaline phosphatase levels, relative to Tacrine hydrochloride hydrate- but not saline- treated rats evaluated by conditioned-place preference.
9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | S3639 | Tacrine hydrochloride hydrate | 206658-92-6 | 1g | 7944.3元 |
2024/01/16 | S3639 | 9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物 Tacrine hydrochloride hydrate | 206658-92-6 | 25mg | 1040.61元 |
9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物
生产厂家
206658-92-6, 9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物 相关搜索:
- Inhibitors
- 抑制剂
- 小分子抑制剂,天然产物
- 小分子抑制剂
- C13H15ClN2xH2O
- 4-四氢吖啶 盐酸盐 水合物
- 他克林盐酸盐一水合物
- 盐酸他克林水合物
- 他克林盐酸盐水合物
- 他克林盐酸盐
- 单满吖啶氨 盐酸盐 水合物
- THA 盐酸盐 水合物
- 206658-92-6
- Cholinesterase (ChE),inhibit,Tacrine hydrochloride (hydrate),Inhibitor
- Tacrine HCl hydrate
- 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+%