NS1652
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- CAS号:
- 1566-81-0
- 英文名:
- NS1652
- 英文别名:
- NS1652;2-(3-(3-(Trifluoromethyl)phenyl)ureido)benzoic acid;Benzoic acid, 2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;Cl? Channels,NS-1652,inhibit,Inhibitor,Chloride Channel,NS1652,NS 1652
- 中文名:
- NS1652
- 中文别名:
- 化合物NS1652;2-(3-(3-(三氟甲基)苯基)脲基)苯甲酸
- CBNumber:
- CB63384783
- 分子式:
- C15H11F3N2O3
- 分子量:
- 324.25
- MOL File:
- 1566-81-0.mol
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NS1652化学性质
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熔点:
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169-171 °C
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沸点:
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355.9±42.0 °C(Predicted)
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密度:
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1.501±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 5 mg/mL (15.42 mM)
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形态:
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Solid
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酸度系数(pKa):
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3.51±0.36(Predicted)
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颜色:
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White to off-white
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NS1652性质、用途与生产工艺
NS1652 是一种可逆的阴离子电导 (anion conductance) 抑制剂,在人和小鼠的红细胞中,可以抑制氯离子通道 (chloride channel),IC50 值为 1.6 μM。
IC50: 1.6 μM (chloride channel, human and mouse red blood cell)
NS1652 potently inhibits the chloride conductance (IC
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, 1.6 μM) in human and mouse red blood cells, but only weakly inhibits VRAC (IC
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, 125 μM) in HEK293 cells. NS1652 markedly blocks the NO production with an IC
50
of 3.1 μM in BV2 cells. NS1652 also down-regulates iNOS expression at 3 μM, and completely abolishes at 10 μM in BV2 cells. NS1652 (0, 1.0, 3.3, 10, and 20 μM) causes increasing hyperpolarization due to inhibition of the chloride conductance in normal erythrocytes. NS1652 lowers the net KCl loss from deoxygenated sickle cells from about 12 mM cells/h to about 4 mM cells/h. NS1652 (20 μM) completely and reversiblely inhibits the red cell Cl
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conductance.
NS1652 (50 mg/kg, i.v.) blocks murine erythrocyte Cl
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conductance by >90% in mice.
NS1652
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-100244 | NS1652 NS1652 | 1566-81-0 | 1mg | 1000元 |
2024/08/19 | HY-100244 | NS1652 NS1652 | 1566-81-0 | 5mg | 2200元 |
1566-81-0, NS1652 相关搜索:
- 药靶配体
- 2-(3-(3-(三氟甲基)苯基)脲基)苯甲酸
- 化合物NS1652
- 1566-81-0
- Cl? Channels,NS-1652,inhibit,Inhibitor,Chloride Channel,NS1652,NS 1652
- 2-(3-(3-(Trifluoromethyl)phenyl)ureido)benzoic acid
- Benzoic acid, 2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-
- NS1652