GW 803430
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- CAS号:
- 515141-51-2
- 英文名:
- GW 803430
- 英文别名:
- GW 3430;GW 803430;GW-803430A;GW 803430,GW803430;GW-803430 >=98% (HPLC);Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy];6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one;6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one;Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
- 中文名:
- GW 803430
- 中文别名:
- 化合物 T15450
- CBNumber:
- CB72538276
- 分子式:
- C25H24ClN3O3S
- 分子量:
- 481.99
- MOL File:
- 515141-51-2.mol
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GW 803430化学性质
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沸点:
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677.7±65.0 °C(Predicted)
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密度:
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1.37±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥4mg/mL at warmed to 60°C
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形态:
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powder
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酸度系数(pKa):
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9.52±0.20(Predicted)
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颜色:
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white to beige
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GW 803430性质、用途与生产工艺
GW-803430 (GW-3430) 是一种有效的选择性黑色素浓缩激素受体 1 (MCH R1) 拮抗剂，pIC50 为 9.3。GW-803430 在肥胖动物模型中具有口服活性。
GW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC
50
value of ~13 nM.
GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls.
GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t
1/2
=11 h) and brain penetration (6:1 brain:plasma concentration) in mice.
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Animal Model:
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High fat diet-induced obese AKR/J mice
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Dosage:
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0.3, 3, and 15 mg/kg
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Administration:
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Orally, qd,12 days
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Result:
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Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls.
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GW 803430
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-11083 | GW-803430 | | 1 mg | 2045元 |
| 2024/04/30 | HY-11083 | GW 803430
GW-803430 | 515141-51-2 | 5mg | 4500元 |
515141-51-2, GW 803430 相关搜索:
- 化合物 T15450
- 515141-51-2
- GW 803430,GW803430
- GW-803430 >=98% (HPLC)
- 6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one
- Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
- GW-803430A
- 6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one
- GW 3430
- GW 803430
- Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]