GW 803430
| 中文名称 | GW 803430 |
|---|---|
| 中文同义词 | 化合物 T15450 |
| 英文名称 | GW 803430 |
| 英文同义词 | Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy];GW 803430;GW 3430;6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one;GW-803430A;Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-;6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one;GW-803430 >=98% (HPLC) |
| CAS号 | 515141-51-2 |
| 分子式 | C25H24ClN3O3S |
| 分子量 | 481.99 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 515141-51-2.mol |
| 结构式 |  |
GW 803430 性质
| 沸点 | 677.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.37±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：加热至 60°C 时≥4mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 9.52±0.20(Predicted) |
| 颜色 | 白色至米色 |
GW-803430 (GW-3430) 是一种有效的选择性黑色素浓缩激素受体 1 (MCH R1) 拮抗剂，pIC50 为 9.3。GW-803430 在肥胖动物模型中具有口服活性。
pIC50: 9.3 (MCH R1)
GW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC 50 value of ~13 nM.
GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls.
GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t
1/2
=11 h) and brain penetration (6:1 brain:plasma concentration) in mice.
| Animal Model: | High fat diet-induced obese AKR/J mice |
| Dosage: | 0.3, 3, and 15 mg/kg |
| Administration: | Orally, qd,12 days |
| Result: | Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-11083 | GW-803430 | 1 mg | 2045元 | |
| 2024/04/30 | HY-11083 | GW 803430 GW-803430 | 515141-51-2 | 5mg | 4500元 |