SB 243213 HYDROCHLORIDE

生物活性靶点体外研究体内研究 SB 243213 HYDROCHLORIDE 试剂级价格

CAS号:: 200940-23-4

英文名:: SB 243213 dihydrochloride

英文别名:: SB 243213 hydrochloride;SB 243213 dihydrochloride;2,3-Dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-Indole-1-carboxamide dihydrochloride;1H-Indole-1-carboxamide, 2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-, hydrochloride (1:1)

中文名:: SB 243213 HYDROCHLORIDE

中文别名:: 化合物 T12859

CBNumber:: CB72574689

分子式:: C22H20ClF3N4O2

分子量:: 464.87

MOL File:: 200940-23-4.mol

化学性质安全信息用途价格供应商 12

SB 243213 HYDROCHLORIDE化学性质

储存条件:: Store at -20°C

溶解度:: Soluble to 50 mM in DMSO

形态:: Powder

安全信息

SB 243213 HYDROCHLORIDE性质、用途与生产工艺

生物活性

SB 243213 hydrochloride 是一种口服有效的，选择性的，高亲和力的 5-HT2C 受体拮抗剂，对人 5-HT2C 受体的 pKi 为 9.37，pKb 为 9.8。SB 243213 hydrochloride 对多种神经递质受体、酶和离子通道具有超过 100 倍的选择性。SB 243213 hydrochloride 具有改善的抗焦虑特性，有用于精神分裂症和运动障碍的潜力。

靶点

Human 5-HT _2C Receptor

9.37 (pKi)

human 5-HT _1A Receptor

<5.3 (pKi)

human 5-HT _1B Receptor

5.5 (pKi)

human 5-HT _1D Receptor

6.32 (pKi)

human 5-HT _1E Receptor

<5.4 (pKi)

human 5-HT _1F Receptor

5.35 (pKi)

Human 5-HT _2A Receptor

7.01 (pKi)

human 5-HT _2B Receptor

7.2 (pKi)

Human 5-HT ₆ Receptor

6.5 (pKi)

Human 5-HT ₇ Receptor

5.64 (pKi)

SB 243213 hydrochloride shows little affinity (pK _i <6) for cloned human 5-HT _1A , 5-HT _1B , 5-HT _1E , 5- HT _1F and 5-HT ₇ receptors. It shows weak affinity (pK _i <6.5) for the cloned human 5-HT _1D and D3 receptors and moderate affinity (pK _i =6.7) for the cloned human D2 receptor.
SB 243213 hydrochloride shows 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels.

体内研究

SB 243213 hydrochloride (0.1-10 mg/kg, p.o. 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.
SB 243213 hydrochloride (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction.

Animal Model:	Male Sprague-Dawley experimentally naive rats (220-300 g)
Dosage:	0.1, 0.3, 1, 3, 10 mg/kg
Administration:	PO; 1 hour pre-test
Result:	Dose-dependently and significantly increased the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.

SB 243213 HYDROCHLORIDE 上下游产品信息

上游原料

下游产品

SB 243213 HYDROCHLORIDE 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2023/03/20	HY-103112	SB 243213 HYDROCHLORIDE SB 243213 hydrochloride	200940-23-4	5mg	900元
2023/03/20	HY-103112	SB 243213 HYDROCHLORIDE SB 243213 hydrochloride	200940-23-4	10mg	1500元

SB 243213 HYDROCHLORIDE 生产厂家

全球有 12家供应商 SB 243213 HYDROCHLORIDE国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	美国	14059	65
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	美国	8449	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
成都超九八生物科技有限公司	13348960310 13348960310	3003867561@qq.com	中国	9946	58
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24023	58
Aladdin Scientific Corporation	+1-833-552-7181	sales@aladdinsci.com	美国	52927	58
ApexBio技术		sales@apexbt.com	美国	6254	58

200940-23-4, SB 243213 HYDROCHLORIDE 相关搜索:

C22H19F3N4O22HCl
化合物 T12859
200940-23-4
1H-Indole-1-carboxamide, 2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-, hydrochloride (1:1)
2,3-Dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-Indole-1-carboxamide dihydrochloride
SB 243213 hydrochloride
SB 243213 dihydrochloride