SB 243213 HYDROCHLORIDE
| 中文名称 | SB 243213 HYDROCHLORIDE |
|---|---|
| 中文同义词 | 化合物 T12859 |
| 英文名称 | SB 243213 dihydrochloride |
| 英文同义词 | SB 243213 dihydrochloride;SB 243213 hydrochloride;2,3-Dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-Indole-1-carboxamide dihydrochloride;1H-Indole-1-carboxamide, 2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-, hydrochloride (1:1) |
| CAS号 | 200940-23-4 |
| 分子式 | C22H20ClF3N4O2 |
| 分子量 | 464.87 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 200940-23-4.mol |
| 结构式 |  |
SB 243213 HYDROCHLORIDE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 在DMSO中溶解至50mM |
| 形态 | 粉末 |
|
Human 5-HT 2C Receptor 9.37 (pKi) |
human 5-HT 1A Receptor <5.3 (pKi) |
human 5-HT 1B Receptor 5.5 (pKi) |
human 5-HT 1D Receptor 6.32 (pKi) |
human 5-HT 1E Receptor <5.4 (pKi) |
human 5-HT 1F Receptor 5.35 (pKi) |
Human 5-HT 2A Receptor 7.01 (pKi) |
human 5-HT 2B Receptor 7.2 (pKi) |
Human 5-HT 6 Receptor 6.5 (pKi) |
Human 5-HT 7 Receptor 5.64 (pKi) |
SB 243213 hydrochloride shows little affinity (pK
i
<6) for cloned human 5-HT
1A
, 5-HT
1B
, 5-HT
1E
, 5- HT
1F
and 5-HT
7
receptors. It shows weak affinity (pK
i
<6.5) for the cloned human 5-HT
1D
and D3 receptors and moderate affinity (pK
i
=6.7) for the cloned human D2 receptor.
SB 243213 hydrochloride shows 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels.
SB 243213 hydrochloride (0.1-10 mg/kg, p.o. 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.
SB 243213 hydrochloride (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction.
| Animal Model: | Male Sprague-Dawley experimentally naive rats (220-300 g) |
| Dosage: | 0.1, 0.3, 1, 3, 10 mg/kg |
| Administration: | PO; 1 hour pre-test |
| Result: | Dose-dependently and significantly increased the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2023/03/20 | HY-103112 | SB 243213 HYDROCHLORIDE SB 243213 hydrochloride | 200940-23-4 | 5mg | 900元 |
| 2023/03/20 | HY-103112 | SB 243213 HYDROCHLORIDE SB 243213 hydrochloride | 200940-23-4 | 10mg | 1500元 |