普啉索旦
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- CAS号:
- 111786-07-3
- 英文名:
- Prinoxodan
- 英文别名:
- RGW2938;Prinoxodan;Prinoxodan (RGW2938);2(1H)-Quinazolinone, 3,4-dihydro-3-methyl-6-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-
- 中文名:
- 普啉索旦
- 中文别名:
- 普啉索旦;化合物 T12720
- CBNumber:
- CB81118261
- 分子式:
- C13H14N4O2
- 分子量:
- 258.28
- MOL File:
- 111786-07-3.mol
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普啉索旦化学性质
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熔点:
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>250 °C
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密度:
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1.47±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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13.58±0.40(Predicted)
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普啉索旦性质、用途与生产工艺
Prinoxodan (RGW2938) 是一种磷酸二酯酶抑制剂。
Prinoxodan (RG W-2938) is an orally effective positive inotropic/vasodilator agent. Prinoxodan is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vitro in isolated guinea pig hearts; in the latter, Prinoxodan 5 nmol-5 μmol increases contractility in a dose-related fashion.
Prinoxodan (RG W-2938) is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vivo in anesthetized and conscious dogs. Prinoxodan 30-300 μg/kg administered intravenously (i.v.) to anesthetized dogs increases contractile force while decreasing arterial pressure and total peripheral resistance (TPR) in a dose-related manner. Heart rate (HR) is only slightly increased, and aortic flow is not appreciably altered. A single oral dose of Prinoxodan 0.3 mg/kg administered to conscious chronically instrumented dogs produces a marked and sustained increase in contractility 15-240 min after treatment while only slightly increasing HR. The effects of Prinoxodan 30-300 μg/kg, i.v. are studied in a mecamylamine-propranolol-induced model of heart failure. Prinoxodan effectively reverses the drug-induced heart failure by increasing myocardial contractility and decreasing arterial pressure while only slightly affecting HR.
普啉索旦
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-U00208 | 普啉索旦 Prinoxodan | 111786-07-3 | 1mg | 2500元 |
2024/04/30 | HY-U00208 | Prinoxodan | | 5 mg | 6200元 |
111786-07-3, 普啉索旦 相关搜索:
- 化合物 T12720
- 普啉索旦
- 111786-07-3
- 2(1H)-Quinazolinone, 3,4-dihydro-3-methyl-6-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-
- Prinoxodan (RGW2938)
- RGW2938
- Prinoxodan