IBERIOTOXIN毒素肽
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- CAS号:
- 129203-60-7
- 英文名:
- IBERIOTOXIN
- 英文别名:
- IBTX;RLBTX;IBERIOTOXIN;IBERIOTOXIN 98%;Iberiotoxin Standard;IBERIOTOXIN USP/EP/BP;IBERIOTOXIN, RECOMBINANT;IBERIOTOXIN, BUTHUS TAMULUS;129203-60-7/182897-30-9（TFA);M.W. 4230.91 C179H274N50O55S7
- 中文名:
- IBERIOTOXIN毒素肽
- 中文别名:
- 伊贝毒素;伊比蝎毒素;伊比(利亚)蝎毒素;IBERIOTOXIN毒素肽;毒素多肽IBERIOTOXIN
- CBNumber:
- CB8130448
- 分子式:
- C179H274N50O55S7
- 分子量:
- 4230.84786
- MOL File:
- 129203-60-7.mol
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IBERIOTOXIN毒素肽化学性质
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储存条件:
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-20°C
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溶解度:
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H2O: 1 mg/mL, clear, colorless
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形态:
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Salt-free lyophilized solid
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水溶解性:
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Soluble to 0.70 mg/ml in water
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IBERIOTOXIN毒素肽性质、用途与生产工艺
Iberiotoxin 是一种从 Buthus tamulus 毒液中分离出来的毒素。Iberiotoxin 是一种选择性的高电导率 Ca2+ 激活的 K+ 通道 (Ca2+-activated K+ channel) 抑制剂，Kd 约为 1 nM。Iberiotoxin 不阻断其他类型的电压依赖性离子通道。
Kd: 1 nM (Ca
2+
-activated K
+
channel)
Iberiotoxin reversibly blocks Ca2+-activated K+ channel in excised membrane patches from bovine aortic smooth muscle. Iberiotoxin acts exclusively at the outer face of the channel and functions with IC
50
values of about 250 pM. Iberiotoxin is a partial inhibitor of
125
I-charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (Ki of 2
50
pM). Iberiotoxin functions as a noncompetitive inhibitor of charybdotoxin binding.
Iberiotoxin treatment affects rat mesenchymal stem cells (rMSCs) migration in the absence of platelet lysate (PL) by inducing a decrease in cell migration suggesting that BK channels regulate rMSCs migration in basal conditions. 10 nM of Iberiotoxin abolishes the PL-induced migration effect on MSCs.
Male Wistar rats (6-7 weeks old) with chronic heart failure (CHF), Iberiotoxin (0.125 nmol/nl, 1.25 nmol/nl and 12.5 nmol/nl) is infused into paraventricular hypothalamic nucleus (PVN) by osmotic minipumps. After perfusion of Iberiotoxin by microinjection of rAAV2-KCNMB4 shRNA virus, right ventricular weight/body weight and lung weight/body weight ratio as well as left ventricular end-diastolic diameter are increased and left ventricular ejection fraction is decreased.
IBERIOTOXIN毒素肽
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-P0190 | IBERIOTOXIN毒素肽
Iberiotoxin | 129203-60-7 | 100μg | 3800元 |
129203-60-7, IBERIOTOXIN毒素肽 相关搜索:
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- Voltage-gated Ion Channels
- Toxins and Venoms
- Scorpion
- Potassium Channel ModulatorsCell Signaling and Neuroscience
- Monovalent Ion Channels
- Potassium Channel ModulatorsPeptides for Cell Biology
- Ion Channel Modulating Peptides
- Potassium channel
- Other
- Enzyme Inhibitors by Type
- Enzyme Inhibitors
- 人、小鼠或大鼠体内的内源性肽
- 多肽
- 目录肽
- 目录多肽
- 标准品
- 毒素肽
- 原料药
- Cell Signaling and Neuroscience
- Cell Biology
- Biochemicals and Reagents
- BioChemical
- Ion Channels
- Monovalent Ion Channels
- Enzyme Inhibitors by Type
- Enzyme Inhibitors
- Enzymes, Inhibitors, and Substrates
- Other
- Potassium Channel Modulators
- Voltage-gated Ion Channels
- C179H273N49O56S7
- C179H274N50O55S7
- 伊比(利亚)蝎毒素
- 伊比蝎毒素
- 伊贝毒素
- 毒素多肽IBERIOTOXIN
- IBERIOTOXIN毒素肽
- 129203-60-7
- 129203-60-7/182897-30-9（TFA)
- Iberiotoxin Standard
- IBERIOTOXIN USP/EP/BP
- Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem
- PYR-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ(DISULFIDE BRIDGE: C7-C28,C13-C33,C17-C35)
- PYR-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ
- RLBTX
- PGLU-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN [DISULFIDE BRIDGES: 7-28, 13-3, 17-3]
- IBERIOTOXIN SCORPION BUTHUS TAMULUS
- IBERIOTOXIN, BUTHUS TAMULUS
- IBERIOTOXIN
- IBTX (SCORPION, BUTHUS TAMULUS)
- IBTX
- IBERIOTOXIN FROM BUTHUS TAMULUS, 50 UG*
- Iberiotoxin, recombinant from Mesobuthus tamulus
- pGlu-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH
- M.W. 4230.91 C179H274N50O55S7
- PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH (DISULFIDE BRIDGE: C7-C28,C13-C33,C17-C35)
- PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH
- IBERIOTOXIN 98%