坎沙曲
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- CAS号:
- 123122-55-4
- 英文名:
- CANDOXATRIL
- 英文别名:
- UK-79300;candoxatril;Candoxatril
(UK 79300);Candoxatril [usan:inn:ban];4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid;4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid;cis-4-[[[1-[(2S)-3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-Methoxyethoxy)Methyl]-3-oxopropyl]cyclopentyl]carbonyl]aMino]cyclohexanecarboxylic Acid;Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-3-[(2,3-dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]-,cis-
- 中文名:
- 坎沙曲
- 中文别名:
- 化合物 T10671
- CBNumber:
- CB82280992
- 分子式:
- C29H41NO7
- 分子量:
- 515.63834
- MOL File:
- 123122-55-4.mol
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坎沙曲化学性质
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熔点:
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107-109°
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比旋光度:
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D -5.8° (c = 1 in methanol)
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沸点:
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718.4±60.0 °C(Predicted)
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密度:
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1.21±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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4.84±0.25(Predicted)
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坎沙曲性质、用途与生产工艺
Candoxatril 是中性肽链内切酶 (NEP) 的一个抑制剂。
While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor.
坎沙曲
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123122-55-4, 坎沙曲 相关搜索:
- Intermediates & Fine Chemicals
- Inhibitors
- Pharmaceuticals
- Chiral Reagents
- Aromatics
- 抑制剂
- C29H41NO7
- 化合物 T10671
- 123122-55-4
- 4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid
- Candoxatril
(UK 79300)
- Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-3-[(2,3-dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]-,cis-
- cis-4-[[[1-[(2S)-3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-Methoxyethoxy)Methyl]-3-oxopropyl]cyclopentyl]carbonyl]aMino]cyclohexanecarboxylic Acid
- candoxatril
- Candoxatril [usan:inn:ban]
- UK-79300
- 4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid