坎沙曲
| 中文名称 | 坎沙曲 |
|---|---|
| 中文同义词 | 化合物 T10671 |
| 英文名称 | CANDOXATRIL |
| 英文同义词 | 4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid;UK-79300;Candoxatril [usan:inn:ban];candoxatril;cis-4-[[[1-[(2S)-3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-Methoxyethoxy)Methyl]-3-oxopropyl]cyclopentyl]carbonyl]aMino]cyclohexanecarboxylic Acid;Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-3-[(2,3-dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]-,cis-;Candoxatril (UK 79300);4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid |
| CAS号 | 123122-55-4 |
| 分子式 | C29H41NO7 |
| 分子量 | 515.63834 |
| EINECS号 | |
| 相关类别 | Aromatics;Chiral Reagents;Pharmaceuticals;Inhibitors;Intermediates & Fine Chemicals |
| Mol文件 | 123122-55-4.mol |
| 结构式 |  |
坎沙曲 性质
| 熔点 | 107-109° |
|---|---|
| 比旋光度 | D -5.8° (c = 1 in methanol) |
| 沸点 | 718.4±60.0 °C(Predicted) |
| 密度 | 1.21±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 4.84±0.25(Predicted) |
Candoxatril 是中性肽链内切酶 (NEP) 的一个抑制剂。
NEP.
While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor.