1140525-25-2
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- CAS号:
- 1140525-25-2
- 英文名:
- SB 290157 trifluoroacetate salt
- 英文别名:
- SB290157 (trifluoroacetate);SB 290157 trifluoroacetate salt;SB 290157 - CAS 1140525-25-2 - Calbiochem;SB 290157 TRIFLUOROACETATE; SB-290157 TRIFLUOROACETATE;N2-(2-(2,2-diphenylethoxy)acetyl)-L-arginine, 2,2,2-trifluor;N2-(2-(2,2-diphenylethoxy)acetyl)-L-arginine (trifluoroacetate);(2S)-5-(diaminomethylideneamino)-2-[[2-(2,2-diphenylethoxy)acetyl]amino]pentanoic acid;SB290157,SB-290157 trifluoroacetate,Inhibitor,inhibit,SB 290157,Complement System,SB-290157,SB290157 trifluoroacetate
- 中文名:
- 1140525-25-2
- 中文别名:
- SB290157 三氟乙酸盐;化合物SB290157 TRIFLUOROACETATE;N2-[2-(2,2-二苯基乙氧基)乙酰基]-L-精氨酸三氟乙酸盐
- CBNumber:
- CB82537362
- 分子式:
- C24H29F3N4O6
- 分子量:
- 526.51
- MOL File:
- 1140525-25-2.mol
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1140525-25-2化学性质
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熔点:
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>43°C (dec.)
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储存条件:
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-20°C
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溶解度:
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Ethanol (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
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形态:
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powder
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颜色:
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white to beige
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旋光性 (optical activity):
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[α]/D +1.5 to +5°, c = 1.0 in DMSO
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稳定性:
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Hygroscopic
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1140525-25-2性质、用途与生产工艺
SB290157 trifluoroacetate (SB 290157 TFA) 是一种有效的 C3a receptor (C3aR) 的竞争性、选择性的拮抗剂，对RBL-C3aR的IC50值为200 nM。
| Target | Value |
RBL-C3aR
(Cell-free assay)
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200 nM
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SB 290157, functions as a competitive antagonist of
125
I-C3a radioligand binding to rat basophilic leukemia-2H3 cells expressing the human C3aR (RBL-C3aR), with an IC
50
of 200 nM. SB 290157 blocks C3a-induced C3aR internalization in a concentration-dependent manner and C3a-induced Ca
2+
mobilization in RBL-C3aR cells and human neutrophils with IC
50
s f 27.7 and 28 nM, respectively. SB 290157 is selective for the C3aR in that it does not antagonize the C5aR or six other chemotactic G protein-coupled receptors. SB 290157 also inhibits C3a-induced Ca
2+
mobilization of RBL-2H3 cells expressing the mouse and guinea pig C3aRs. It potently inhibits C3a-mediated ATP release from guinea pig platelets and inhibits C3a-induced potentiation of the contractile response to field stimulation of perfused rat caudal artery.
SB 290157, inhibits neutrophil recruitment in a guinea pig LPS-induced airway neutrophilia model and decreases paw edema in a rat adjuvant-induced arthritis model. The antagonist is able to reduce joint swelling only at 3 h, and about 50% inhibition of joint swelling is observed with the concentration of 30 mg/kg. The C3 level is significantly decreased at 3 h compared with naive mice showing complement consumption. Furthermore, the C3 activation is observed and increased corresponding to the graded concentration of anti-OVA pAb.
1140525-25-2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101502A | SB290157 trifluoroacetate | | 1 mg | 272元 |
| 2024/04/30 | HY-101502A | 1140525-25-2
SB290157 trifluoroacetate | 1140525-25-2 | 10mM * 1mLin DMSO | 695元 |
1140525-25-2, 1140525-25-2 相关搜索:
- 药靶配体
- 氨基酸
- C22H28N4O4CF3COOH
- SB290157 三氟乙酸盐
- 化合物SB290157 TRIFLUOROACETATE
- N2-[2-(2,2-二苯基乙氧基)乙酰基]-L-精氨酸三氟乙酸盐
- 1140525-25-2
- SB290157,SB-290157 trifluoroacetate,Inhibitor,inhibit,SB 290157,Complement System,SB-290157,SB290157 trifluoroacetate
- N2-(2-(2,2-diphenylethoxy)acetyl)-L-arginine (trifluoroacetate)
- N2-(2-(2,2-diphenylethoxy)acetyl)-L-arginine, 2,2,2-trifluor
- (2S)-5-(diaminomethylideneamino)-2-[[2-(2,2-diphenylethoxy)acetyl]amino]pentanoic acid
- SB 290157 - CAS 1140525-25-2 - Calbiochem
- SB 290157 TRIFLUOROACETATE; SB-290157 TRIFLUOROACETATE
- SB290157 (trifluoroacetate)
- SB 290157 trifluoroacetate salt