TYROSINE KINASE-IN-1
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- CAS号:
- 705946-27-6
- 英文名:
- XL999
- 英文别名:
- XL999;XL999;XL 999;Tyrosine kinase-IN-1;Tyrosine kinase inhibitor 1;XL-999(Tyrosine kinase-IN-1);(Z)-5-((1-Ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene)indolin-2-one;2H-Indol-2-one, 5-[(1-ethyl-4-piperidinyl)amino]-3-[(3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene]-1,3-dihydro-, (3Z)-;Tyrosine kinase IN 1,FGFR,Inhibitor,VEGFR,Platelet-derived growth factor receptor,Vascular endothelial growth factor receptor,Fibroblast growth factor receptor,inhibit,PDGFR,Tyrosine kinaseIN1
- 中文名:
- TYROSINE KINASE-IN-1
- 中文别名:
- 化合物TYROSINE KINASE-IN-1;(Z)-5-((1-乙基哌啶-4-基)氨基O)-3-((3-氟苯基)(5-甲基-1H-咪唑-2-基)亚甲基)吲哚啉-2-酮
- CBNumber:
- CB82731166
- 分子式:
- C26H28FN5O
- 分子量:
- 445.53
- MOL File:
- 705946-27-6.mol
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TYROSINE KINASE-IN-1化学性质
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密度:
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1.280±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 62.5 mg/mL (140.28 mM)
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酸度系数(pKa):
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11.67±0.20(Predicted)
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TYROSINE KINASE-IN-1性质、用途与生产工艺
Tyrosine kinase-IN-1是多靶点的酪氨酸激酶抑制剂，抑制 KDR，Flt-1，FGFR1 和 PDGFRα 的 IC50 值分别为4，20，4，2 nM。
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Flt-1
4 nM (IC
50
)
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KDR
20 nM (IC
50
)
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PDGFRα
4 nM (IC
50
)
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FGFR1
2 nM (IC
50
)
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Tyrosine kinase-IN-1 is from reference (compound 8K).
Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(
0–∞
)=1.9, t
1/2
=4.6 h). It has a favorable oral bioavailability (F=63%) in rats.
TYROSINE KINASE-IN-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100315 | TYROSINE KINASE-IN-1
Tyrosine kinase-IN-1 | 705946-27-6 | 1mg | 450元 |
| 2024/04/30 | HY-100315 | TYROSINE KINASE-IN-1
Tyrosine kinase-IN-1 | 705946-27-6 | 5mg | 700元 |
TYROSINE KINASE-IN-1
生产厂家
705946-27-6, TYROSINE KINASE-IN-1 相关搜索:
- 合成有机化合物配体
- (Z)-5-((1-乙基哌啶-4-基)氨基O)-3-((3-氟苯基)(5-甲基-1H-咪唑-2-基)亚甲基)吲哚啉-2-酮
- 化合物TYROSINE KINASE-IN-1
- 705946-27-6
- (Z)-5-((1-Ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene)indolin-2-one
- XL-999(Tyrosine kinase-IN-1)
- Tyrosine kinase IN 1,FGFR,Inhibitor,VEGFR,Platelet-derived growth factor receptor,Vascular endothelial growth factor receptor,Fibroblast growth factor receptor,inhibit,PDGFR,Tyrosine kinaseIN1
- 2H-Indol-2-one, 5-[(1-ethyl-4-piperidinyl)amino]-3-[(3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene]-1,3-dihydro-, (3Z)-
- XL999;XL 999
- Tyrosine kinase inhibitor 1
- Tyrosine kinase-IN-1
- XL999