酪氨酸磷酸化抑制剂AG528
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- CAS号:
- 133550-49-9
- 英文名:
- TYRPHOSTIN AG 528
- 英文别名:
- CS-2282;TYRPHOSTIN AG-528 (TYRPHOSTIN B66);(E)-3-(3,4-Dihydroxyphenyl)-2-(indoline-1-carbonyl)acrylonitrile;N-(3μ,4μ-Dihydroxybenzylidenecyanoacetyl)indoline, Tyrphostin B66;1H-Indole-1-propanenitrile, α-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-β-oxo-, (αE)-;Tyrphostin AG 528,AG528,HER1,Tyrphostin AG-528,ErbB-1,AG-528,EGFR,Tyrphostin AG528,Tyrphostin B-66,Tyrphostin B 66,inhibit,Epidermal growth factor receptor,Inhibitor
- 中文名:
- 酪氨酸磷酸化抑制剂AG528
- 中文别名:
- 酪氨酸磷酸化抑制剂AG528;TYRPHOSTIN AG 528游离;化合物TYRPHOSTIN AG 528
- CBNumber:
- CB9972771
- 分子式:
- C18H14N2O3
- 分子量:
- 306.32
- MOL File:
- 133550-49-9.mol
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酪氨酸磷酸化抑制剂AG528化学性质
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熔点:
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215 °C
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沸点:
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529.4±50.0 °C(Predicted)
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密度:
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1.416±0.06 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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8.80±0.10(Predicted)
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酪氨酸磷酸化抑制剂AG528性质、用途与生产工艺
Tyrphostin AG-528 (Tyrphostin B66) 是一种 epidermal growth factor receptors (EGFR) 和 ErbB2/HER2 的有效抑制剂，其IC50值分别为4.9 μM和2.1 μM。Tyrphostin AG-528 具有抗癌活性。
| Target | Value |
HER2
(Cell-free assay)
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2.1 μM
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EGFR
(Cell-free assay)
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4.9 μM
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In the present study, the interaction between drug Tyrphostin AG528 and CNT(6,6-6) nanotube by Density Functional Theory (DFT) calculations in solvent water has been investigated for the first time. According to the calculations, intermolecular hydrogen bonds take place between an active position of the molecule Tyrphostin AG528 and hydrogen atoms of the nanotube which play an important role in the stability of complex CNT(6,6- 6)/Tyrphostin AG528. The non-bonded interaction effects of the molecule Tyrphostin AG528 with CNT(6,6-6) nanotube on the electronic properties, chemical shift tensors and natural charge have also been detected. The natural bond orbital (NBO) analysis suggested that the molecule Tyrphostin AG528 as an electron donor and the CNT(6,6-6) nanotube play the role of an electron acceptor at the complex CNT(6,6-6)/Tyrphostin AG528.
酪氨酸磷酸化抑制剂AG528
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | T3504 | 酪氨酸磷酸化抑制剂AG528
Tyrphostin AG528 | 133550-49-9 | 25mg | 680元 |
| 2024/04/30 | S6805 | 酪氨酸磷酸化抑制剂AG528
Tyrphostin AG-528 | 133550-49-9 | 5mg | 794.13元 |
133550-49-9, 酪氨酸磷酸化抑制剂AG528 相关搜索:
- 生化试剂
- TYRPHOSTIN AG 528游离
- 化合物TYRPHOSTIN AG 528
- 酪氨酸磷酸化抑制剂AG528
- 133550-49-9
- Tyrphostin AG 528,AG528,HER1,Tyrphostin AG-528,ErbB-1,AG-528,EGFR,Tyrphostin AG528,Tyrphostin B-66,Tyrphostin B 66,inhibit,Epidermal growth factor receptor,Inhibitor
- (E)-3-(3,4-Dihydroxyphenyl)-2-(indoline-1-carbonyl)acrylonitrile
- 1H-Indole-1-propanenitrile, α-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-β-oxo-, (αE)-
- TYRPHOSTIN AG-528 (TYRPHOSTIN B66)
- CS-2282
- N-(3μ,4μ-Dihydroxybenzylidenecyanoacetyl)indoline, Tyrphostin B66