呋喃洛芬
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- CAS号:
- 67700-30-5
- 英文名:
- furaprofen
- 英文别名:
- furaprofen;furaprofen USP/EP/BP;7-Benzofuranacetic acid, α-methyl-3-phenyl-;2-(3-phenyl-1-benzofuran-7-yl)propanoic acid
- 中文名:
- 呋喃洛芬
- 中文别名:
- 呋喃洛芬;化合物 T16715
- CBNumber:
- CB8908528
- 分子式:
- C17H14O3
- 分子量:
- 266.295
- MOL File:
- 67700-30-5.mol
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呋喃洛芬化学性质
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沸点:
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449.4±33.0 °C(Predicted)
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密度:
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1.230±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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4?+-.0.30(Predicted)
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颜色:
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White to light yellow
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呋喃洛芬性质、用途与生产工艺
Furaprofen (R803) 是一种有效的 HCV 复制抑制剂。作用于 HCV 基因型 1a 和 1b 复制子时 EC50 约为 30 nM,作用于基因型 2a 复制子时 EC50 约为 1000 nM。
EC50: ~30 nM (HCV genotype 1a and 1b replicons), ~1000 nM (HCV genotype 2a replicon)
Furaprofen (R803) is potent and highly specific for HCV replication. The antiviral activity of Furaprofen has been determined by a reporter replicon assay with multiple repeats to be 29.88±8.05 nM, an ~3-fold improvement over the activity of the parent compound, R706. The potency of Furaprofen against the replicon is also confirmed by both Western blotting and TaqMan RT-PCR to be about 37 nM and 54.67±4.11 nM, respectively. To assess the general effect of Furaprofen on cell proliferation, a panel of primary cells and transformed human cell lines are treated with increasing doses of Furaprofen for 48 h, and the effect on cell proliferation is measured by an MTS-based cell viability assay. The the concentration that caused a 50% reduction in cell numbers in the absence of virus infection (CC
50
) of Furaprofen is found to range from 2 μM to ≥10 μM, depending on the cell type and proliferation status.
呋喃洛芬
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-U00213 | Furaprofen | | 1 mg | 3400元 |
2024/08/19 | HY-U00213 | 呋喃洛芬 Furaprofen | 67700-30-5 | 5mg | 8500元 |
67700-30-5, 呋喃洛芬 相关搜索:
- 化合物 T16715
- 呋喃洛芬
- 67700-30-5
- furaprofen USP/EP/BP
- 7-Benzofuranacetic acid, α-methyl-3-phenyl-
- 2-(3-phenyl-1-benzofuran-7-yl)propanoic acid
- furaprofen