阿珠莫林
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- CAS号:
- 64748-79-4
- 英文名:
- Azumolene
- 英文别名:
- Azumolene;EU4093 free base;1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]hydantoin;2,4-Imidazolidinedione, 1-[[[5-(4-bromophenyl)-2-oxazolyl]methylene]amino]-;SOCE,inhibit,Azumolene,EU-4093,ryanodine,Inhibitor,Ca channels,EU 4093,Calcium Channel,relaxant,Ca2+ channels,muscle,EU4093,receptor,calcium
- 中文名:
- 阿珠莫林
- 中文别名:
- 阿珠莫林
- CBNumber:
- CB91178079
- 分子式:
- C13H9BrN4O3
- 分子量:
- 349.14
- MOL File:
- 64748-79-4.mol
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阿珠莫林化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 13.89 mg/mL (39.78 mM)
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阿珠莫林性质、用途与生产工艺
Azumolene (EU4093 free base)，一种 Dantrolene 的类似物，是一种肌肉松弛剂。Azumolene 是一种 ryanodine 受体 (ryanodine receptor (RyR)) 调节剂，并通过 ryanodine 受体抑制钙释放。Azumolene 可用于恶性高热研究。
Pretreatment with 20 µM Azumolene for 1-2 min inhibits SOCE activated by subsequent addition of caffeine and ryanodine to promote RyR-dependent sarcoplasmic reticulum Ca
2+
store depletion in mouse myotubes and adult muscle fibers.
The effect of Azumolene (EU4093) on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg/kg. This dose of Azumolene reduces the amplitude of the twitch to 31.9% of the control value. The contraction of intrafusal muscle as measured by the response of spindle afferent discharge is also reduced by Azumolene.
阿珠莫林
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-113920A | Azumolene | | 1 mg | 384元 |
| 2024/04/30 | HY-113920A | 阿珠莫林
Azumolene | 64748-79-4 | 5mg | 960元 |
64748-79-4, 阿珠莫林 相关搜索:
- 药靶配体
- 阿珠莫林
- 64748-79-4
- SOCE,inhibit,Azumolene,EU-4093,ryanodine,Inhibitor,Ca channels,EU 4093,Calcium Channel,relaxant,Ca2+ channels,muscle,EU4093,receptor,calcium
- EU4093 free base
- 2,4-Imidazolidinedione, 1-[[[5-(4-bromophenyl)-2-oxazolyl]methylene]amino]-
- 1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]hydantoin
- Azumolene