(-)-BLEBBISTATIN
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- CAS号:
- 856925-71-8
- 英文名:
- (-)-Blebbistatin
- 英文别名:
- CS-978;(-)-BLEBBISTATIN;(-)-Blebbistcitin;(+/-)-BLEBBISTATIN;(S)-(-)-BLEBBISTATIN;Blebbistatin S enantiomer;(-)-Blebbistatin USP/EP/BP;(-)-Blebbistatin *CAS#: 856925-71-8*;(-)-BLEBBISTATIN;(S)-(-)-BLEBBISTATIN;(-)-Blebbistatin - CAS 856925-71-8 - Calbiochem
- 中文名:
- (-)-BLEBBISTATIN
- 中文别名:
- (-)-博氏定;(?)-布雷他汀;(-)-布雷他汀;(–)-BLEBBISTATIN;化合物(-)-BLEBBISTATIN;细胞抑制剂(-)-BLEBBISTATIN;(S)-(-)-BLEBBISTATIN试剂;MYOSIN II抑制剂((-)-BLEBBISTATIN);(S)-3A-羟基-6-甲基-1-苯基-3,3A-二氢-1H-吡咯[2,3-B]喹啉-4(2H)-酮
- CBNumber:
- CB92129465
- 分子式:
- C18H16N2O2
- 分子量:
- 292.33
- MOL File:
- 856925-71-8.mol
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(-)-BLEBBISTATIN化学性质
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熔点:
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210-212°C
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沸点:
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507.3±60.0 °C(Predicted)
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密度:
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1.31±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: soluble5mg/mL
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形态:
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Yellow solid
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酸度系数(pKa):
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11.15±0.20(Predicted)
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颜色:
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Light Yellow to Yellow
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(-)-BLEBBISTATIN性质、用途与生产工艺
(-)-Blebbistatin ((S)-(-)-Blebbistatin)是一种细胞渗透性抑制剂，作用于非肌球蛋白IIATPase，无细胞试验中IC50为~2 μM，不抑制肌球蛋白轻链激酶 (MLCK)，抑制卵裂沟的缢缩，不干扰有丝分裂或收缩环的组装。
| Target | Value |
non-muscle myosin II ATPases
(Cell-free assay)
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0.5 μM-5 μM
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Blebbistatin抑制细胞分裂，改变鱼角膜细胞的平滑运动，且抑制缺乏细丝蛋白的细胞系进行自发起泡。Blebbistatin抑制非肌肉肌球蛋白IIA，非肌肉肌球蛋白IIB，和兔骨骼肌肌球蛋白S1的HMM片段的酶活性，而不抑制平滑肌球蛋白。Blebbistatin快速且可逆抑制Mg-ATPase活性，也抑制非肌肉肌球蛋白IIA和IIB的体外活性，而极其微弱抑制平滑肌肌球蛋白（IC50=80 μM）。Blebbistatin有效抑制Dictyostelium肌球蛋白II，但极其微弱抑制Acanthamoeba肌球蛋白II。Blebbistatin不抑制代表性的I，V，和X型肌球蛋白超家族成员。Blebbistatin不与核苷酸竞争性结合到骨骼肌肌球蛋白亚片段-1。Blebbistatin优先结合到ATP酶，与ADP和磷酸盐在活性位点相互作用，减慢磷释放。Blebbistatin既不干扰肌球蛋白与肌动蛋白结合，也不干扰ATP诱导的肌动球蛋白解离。
Blebbistatin dose-dependently and completely relax both KCl- and carbachol-induced rat detrusor and endothelin-1-induced human bladder contraction. Pre-incubation with 10 μM blebbistatin attenuates carbachol responsiveness by 65% while blocking electrical field stimulation-induced bladder contraction reaching 50% inhibition at 32 Hz.
用途
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Blebbistatin also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell
. Blebbistatin blocks both blebbing and cytokinesis at 50-100μM.
[Blebbistatin:a]D= -103 (c= 1.21 CHCl3)
(-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one
(-)-BLEBBISTATIN
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-13441 | (-)-BLEBBISTATIN
(-)-Blebbistatin | 856925-71-8 | 5mg | 720元 |
| 2024/01/25 | HY-13441 | (-)-BLEBBISTATIN
(-)-Blebbistatin | 856925-71-8 | 10mg | 990元 |
856925-71-8, (-)-BLEBBISTATIN 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- Chiral Reagents
- Caspases/Apoptosis
- 药靶配体
- 其他生化试剂
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 膜转运
- 离子通道
- (?)-布雷他汀
- (-)-布雷他汀
- (S)-(-)-BLEBBISTATIN试剂
- (S)-3A-羟基-6-甲基-1-苯基-3,3A-二氢-1H-吡咯[2,3-B]喹啉-4(2H)-酮
- 化合物(-)-BLEBBISTATIN
- (-)-博氏定
- (–)-BLEBBISTATIN
- MYOSIN II抑制剂((-)-BLEBBISTATIN)
- 细胞抑制剂(-)-BLEBBISTATIN
- 856925-71-8
- inhibit,Myosin,Inhibitor,( ) Blebbistatin,()Blebbistatin
- (-)-Blebbistatin USP/EP/BP
- (-)-Blebbistcitin
- (S)-3a-hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
- Blebbistatin S enantiomer
- (-)-BLEBBISTATIN;(S)-(-)-BLEBBISTATIN
- (-)-Blebbistatin *CAS#: 856925-71-8*
- CS-978
- (3aS)-3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
- (-)-Blebbistatin - CAS 856925-71-8 - Calbiochem
- (S)-3a-Hydroxy-6-methyl-1-phenyl-3,3a-dihydro-1H-pyrrolo[2,3-b]quinolin-4(2H)-one
- 3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
1,2,3,3atetrahydro3ahydroxy6methyl1phenyl4Hpyrrolo[2,3b]quinolin4one
- 3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one (-)-Blebbistatin
- (S)-(-)-BLEBBISTATIN
- (+/-)-BLEBBISTATIN
- 4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aS)-
- (-)-BLEBBISTATIN