网站主页 >> CAS数据库列表 >> 4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯
4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯
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- CAS号:
- 873697-71-3
- 英文名:
- OMecaMtiv Mecarbil
- 英文别名:
- CS-827;CK1827452;CK-1827452;CK 1827452O;CK1827452, >98%;mecamtiv mecarbil;OMecaMtiv Mecarbil;Omecamtiv mecarbil?, >98%;OMecaMtiv Mecarbil USP/EP/BP;CK-1827452 (OMecaMtiv Mecarbil)
- 中文名:
- 4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯
- 中文别名:
- 化合物OMECAMTIV MECARBIL;MYOSIN激活剂(OMECAMTIV MECARBIL);OMECAMTIV MECARBIL (CK-1827452),心肌肌球蛋白激动剂;4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯;4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯
- CBNumber:
- CB92561487
- 分子式:
- C20H24FN5O3
- 分子量:
- 401.43
- MOL File:
- 873697-71-3.mol
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4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯化学性质
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熔点:
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180℃
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储存条件:
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-20°C Freezer
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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水溶解性:
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40.25mg/L at 25℃
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LogP:
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-0.531
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4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯性质、用途与生产工艺
Omecamtiv mecarbil (CK-1827452)是一种特异性的心肌肌球蛋白激动剂,是用于左心室收缩性心脏衰竭的临床药物。Phase 2。
In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate. In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway.
Omecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure. In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters.
Omecamtiv mecarbil (CK-1827452)是一种特异性的心肌肌球蛋白激动剂,是用于左心室收缩性心脏衰竭的临床药物。Phase 2。
Target | Value |
Myosin ATPase
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在体外,Omecamtiv mecarbil通过增加肌球蛋白ATPase比率,选择性激活心肌肌球蛋白。 在离体心肌细胞中,Omecamtiv mecarbil导致肌细胞收缩性增加,并使肌浆球蛋白抑制剂BDM失效,而不增加钙转运或抑制PDE通路。
在SD大鼠,深水动物和心脏衰竭大鼠体内,Omecamtiv mecarbil在血浆中浓度达到0.4 mM后显著增加缩短分数。在清醒状态下心肌梗死(MI-sHF)的狗体内,Omecamtiv mecarbil显著增加壁室厚度(25%),每搏输出量(44%),心输出量(22%)和左心室 (LV) 收缩射血时间(26%)。此外,Omecamtiv mecarbil也会导致一些血流动力学参数,包括心率,平均左房压,和LV末期舒张压下降。在左心室肥大(LVH-sHF)的清醒的狗体内,Omecamtiv mecarbil对血流动力学参数具有类似且统计学差异化的影响。
4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-14233 | Omecamtiv mecarbil | | 1 mg | 454元 |
2024/04/30 | HY-14233 | 4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯 Omecamtiv mecarbil | 873697-71-3 | 10mM * 1mLin DMSO | 883元 |
4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯
生产厂家
873697-71-3, 4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯 相关搜索:
- Inhibitors
- 药靶配体
- 合成有机化合物配体
- 试剂
- 细胞生物学试剂
- 小分子抑制剂,天然产物
- 小分子抑制剂
- 膜转运
- 离子通道
- C20H24FN5O3
- 4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯
- OMECAMTIV MECARBIL (CK-1827452),心肌肌球蛋白激动剂
- 化合物OMECAMTIV MECARBIL
- MYOSIN激活剂(OMECAMTIV MECARBIL)
- 4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯
- 873697-71-3
- 1-Piperazinecarboxylic acid,4-[[2-fluoro-3-[[[(6-methyl-3-py...
- OMecaMtiv Mecarbil USP/EP/BP
- Omecamtiv mecarbil?, >98%
- CK1827452, >98%
- CS-827
- CK-1827452; CK1827452;CK 1827452
- CK 1827452 - Omecamtiv Mecarbil | CK-452
- OMECAMTIV MECARBIL (CK-1827452);CK1827452
- methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl] piperazine-1-carboxylate
- Methyl 4-[[2-fluoro-3-[N'-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate Omecamtiv mecarbil(CK1827452)
- methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate
- Methyl 4-[[2-fluoro-3-[N'-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate
- mecamtiv mecarbil
- CK 1827452O
- CK-1827452 (OMecaMtiv Mecarbil)
- CK-1827452
- CK1827452
- OMecaMtiv Mecarbil (CK-1827452)
- OMecaMtiv Mecarbil
- 1-Piperazinecarboxylic acid,4-[[2-fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-, methyl ester