粉蝶霉素A
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- CAS号:
- 2738-64-9
- 英文名:
- PIERICIDIN A
- 英文别名:
- SN 198E;IT-143D;piericidin;piericidinea;PIERICIDIN A;PIERICIDIN A1;SHAOGUAMYCIN B;SHAOGUANMYCIN B;piericidin(sub1);piericidin a from microbial source
- 中文名:
- 粉蝶霉素A
- 中文别名:
- 抗生素;菜青素A;杀粉蝶菌素;粉蝶霉素A;杀粉蝶菌素A
- CBNumber:
- CB9758229
- 分子式:
- C25H37NO4
- 分子量:
- 415.57
- MOL File:
- 2738-64-9.mol
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粉蝶霉素A化学性质
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沸点:
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614.9±55.0 °C(Predicted)
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密度:
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1.044±0.06 g/cm3(Predicted)
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闪点:
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85 °C
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储存条件:
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2-8°C
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溶解度:
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Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
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酸度系数(pKa):
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5.21±0.33(Predicted)
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形态:
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liquid
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颜色:
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green-yellow
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month.
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粉蝶霉素A性质、用途与生产工艺
Piericidin A (AR-054) 是一种天然线粒体 NADH-泛醌氧化还原酶 (复合物 I; complex I) 抑制剂。Piericidin A 是一种有效的神经毒素，通过其对 NADH-泛醌还原酶 (NADH-ubiquinone reductase) 的作用破坏电子传输系统，从而抑制线粒体呼吸。Piericidin A 还是一种潜在的群体感应抑制剂，可抑制胡萝卜欧文氏菌亚种 atroseptica (Eca) 的毒力基因的表达。Piericidin A 是一种 ADC 细胞毒素，具有抗菌，抗癌，杀虫活性。
In a cell free assay, the potency of Piericidin A to inhibit mitochondrial complex I is ∼2 fold smaller than the one of annonacin. In cultured neurons, Piericidin A potently induces the redistribution of phosphorylated tau from the dendrites into the cell soma and induces cell death.
The viability of Tn5B1-4 cells is inhibited by Piericidin A in a time- and concentration-dependent manner with IC
50
value of 0.061 μM, whilst Piericidin A shows slight inhibitory effect on the viability of HepG2 and Hek293 cells with IC
50
value of 233.97 μM and 228.96 μM, respectively. Piericidin A induces apoptosis of Tn5B1-4 cells coincides with a decrease in the mitochondrial membrane potential.
Piericidin A (0.5 mg/kg/d; for 28 days via osmotic minipumps) significantly increases the number of phospho-tau immunoreactive cells in the cerebral cortex in P301S
+/+
mice. Piericidin A leads to increased levels of pathologically phosphorylated tau only in P301S
+/+
mice. The synaptic density is reduced by Piericidin A treatment in P301S
+/+
mice. Exposure to Piericidin A aggravates the course of genetically determined tau pathology.
粉蝶霉素A
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-114936 | 粉蝶霉素A
Piericidin A | 2738-64-9 | 1mg(12.03mM * 200μL in Ethanol) | 4500元 |
粉蝶霉素A
生产厂家
全球有 57家供应商
粉蝶霉素A国内生产厂家
2738-64-9, 粉蝶霉素A 相关搜索:
- Antibiotic
- 生化试剂
- 小分子
- 试剂盒-细胞分析试剂盒
- 微生物代谢物
- BioChemical
- Antibiotics A to Z
- Antibiotics
- Antibiotics N-S
- Apoptosis and Cell Cycle
- Cell Signaling and Neuroscience
- Cell Biology
- Mitochondrial Transport Inhibitors
- 杀粉蝶菌素
- 菜青素A
- 杀粉蝶菌素A
- 粉蝶霉素A
- 抗生素
- 2738-64-9
- 4-Pyridinol, 2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-
- 2-[(2E,4E,7E,9S,10S,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,4,7,11-tetraenyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one
- 4-Pyridinol,2-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-5,6-dimethoxy- [R-[R*,R*-(all-E)]]-3-methyl-
- 2,6,9,11-Tridecatetraen-4-ol,13-(4-hydrox-5,6-dimethoxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-(all-E)-(4R,5R)
- ShaoguanMycin B, MT 1882-I, SN 198E, IT 143D, Piericidin A1
- 4-PYRIDINOL,2-(10-HYDROXY-3,7,9,11-TETRAMETHYL-2,5,7,11-TRIDECATETRAENYL)-5,6-DIMETHOXY-, [R-[R*,R*-(ALL-E)]]-3-METHYL-
- IT-143D
- (2E,4S,5S,6E,8E,11E)-13-(5,6-Dimethoxy-4-hydroxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-2,6,8,11-tridecatetren-4-ol
- Piericidin A1, Shaoguamycin B, SN 198E, 2,6,9,11-Tridecatetraen-4-ol,13-(4-hydrox-5,6-dimethoxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-(all-E)-(4R,5R)-(8Cl), 4-Pyridinol,2-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-5,6-dimethoxy- [R-[R*,R*-(all-E)]]-3-methyl-
- piericidin a from microbial source
- PENICILLIN-STREPTOMYCIN (200X PEN-STREP)
- Piericidin A from Streptomyces mobaraensis
- 2,6,9,11-TRIDECATETRAEN-4-OL,13-(4-HYDROX-5,6-DIMETHOXY-3-METHYL-2-PYRIDYL)-3,5,7,11-TETRAMETHYL-(ALL-E)-(4R,5R)-(8CL)
- PIERICIDIN A1
- PIERICIDIN A
- SHAOGUANMYCIN B
- SHAOGUAMYCIN B
- SN 198E
- piericidinea
- piericidin(sub1)
- piericidin
- 2,6,9,11-tridecatetraen-4-ol,13-(4-hydroxy-5,6-dimethoxy-3-methyl-2-pyridyl)-3
- ,5,7,11-tetramethyl-,(all-e)-(4s,5s)-