GLP-1
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- CAS-Nr.
- 87805-34-3
- Englisch Name:
- GLP-1
- Synonyma:
- GLP-1;GLP-1 (HUMAN);GLP-1 USP/EP/BP;Rat GLP-I(1-37);GLP-1, 5mg/vial;GATA-like protein 1;GLP-1 (1-37) (human);PREPROGLUCAGON 72-108;GLUCAGON-LIKE PEPTIDE I;Glucagon-likepeptide1(1-37)
- CBNumber:
- CB0193173
- Summenformel:
- C186H275N51O59
- Molgewicht:
- 4169.48
- MOL-Datei:
- Mol file
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GLP-1 Eigenschaften
- storage temp.
- −20°C
- Aggregatzustand
- Solid
- Wasserlöslichkeit
- Soluble to 5 mg/ml in water
- InChIKey
- UKVFVQPAANCXIL-FJVFSOETSA-N
- CAS Datenbank
- 87805-34-3
GLP-1 Chemische Eigenschaften,Einsatz,Produktion Methoden
History
GLP-1 was first identified in the early 1980s, following the cloning of the proglucagon gene. The biological activity of GLP-1 was investigated initially by using the N-terminal extended forms of GLP-1(1–37 and 1–36 amide). However, these forms were devoid of biological activity. In the late 1980s, bioactive GLP-1 peptides were purified from gut extracts and were identified to be GLP1(7–37) and GLP-1(7–36)-amide. In the current literature, the unqualified designation of GLP-1 corresponds to the truncated peptides.
Verwenden
Glucagon-Like Peptide I (GLP1) has been used as an antigen in excess amounts for the incubation of primary antibodies, post-immunocytochemistry with positive results of paraffin-embedded pancreatic tissues of
Rana temporaria.
Allgemeine Beschreibung
Glucagon-Like Peptide I (GLP1) is an incretin hormone, which functions as ligand for GLP1 receptors (GLP1R). These receptors are expressed in renal and cardiovascular system, such as smooth muscle and endothelial cells.
Biochem/physiol Actions
Glucagon-Like Peptide I (GLP1) controls the metabolism of glucose, by inducing the secretion of insulin and suppressing that of glucagon. Studies in Indonesian population show that reduced levels of this protein are linked with increased susceptibility to type 2 diabetes mellitus. Plasma levels of this hormone also show significant association with systolic and diastolic blood pressure levels.
GLP-1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GLP-1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 122)Lieferanten
87805-34-3()Verwandte Suche:
Glucagon
Phenylselenol
(Ethylenbis(nitrilomethylidyn)-2,2'-diphenolato)cobalt(II)
(p-Toluolsulfonyl)methylisocyanid
1,1,3,3-Tetramethylbutylisocyanat
Kupfer(II)-4-oxopent-2-en-2-olat
Pyranthren-8,16-dion
N-Butylisocyanid
Tris(pentan-2,4-dionato)eisen(II)
Ethylisocyanacetat
Aluminiumtris(2,4-pentandionato-O,O')
Benzylisocyanid
Methylisocyanacetat
Dichloro(ethylendiamin)platin
2-Methylpropylisocyanid
(Pentan-2,4-dionato-O,O')silber
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')europium
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')dysprosium
- HIS-ASP-GLU-PHE-GLU-ARG-HIS-ALA-GLU-GLY- THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARGY-GLY
- GLUCAGON-LIKE PEPTIDE I HUMAN
- GLUCAGON-LIKE PEPTIDE-1, HUMAN
- GLUCAGON-LIKE PEPTIDE I
- GLUCAGON-LIKE PEPTIDE 1 (1-37) (HUMAN)
- GLUCAGON-LIKE PEPTIDE 1 (1-37) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT)
- GLUCAGON-LIKE PEPTIDE 1 (1-37) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT) TRIFLUOROACETATE SALT
- GLP-1
- GLP-1 (1-37) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT)
- GLP-1 (1-37) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT) TRIFLUOROACETATE SALT
- GLP-1 (HUMAN)
- Glucagon-likepeptide1(1-37)
- glucagon-like peptide I (1-37)
- PREPROGLUCAGON 72-108
- PREPROGLUCAGON (92-128) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT) TRIFLUOROACETATE SALT
- PROGLUCAGON (72-108) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT) TRIFLUOROACETATE SALT
- M.W. 4169.54 C186H275N51O59
- HIS-ASP-GLU-PHE-GLU-ARG-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY
- Glucagon-like peptide 1 (1-37) (human, rat)
- GLP-1 (1-37) (huMan, bovine, guinea pig, Mouse, rat)
Preproglucagon (92-128) (huMan, bovine, guinea pig, Mouse, rat), Proglucagon (72-108) (huMan, bovine, guinea pig, Mouse, rat), Glucagon-Like Peptide 1 (1-37) (huMan, bovine, guinea pig, Mouse, rat)
- Preproglucagon (92-128) (huMan, bovine, guinea pig, Mouse, rat), Proglucagon (72-108) (huMan, bovine, guinea pig, Mouse, rat), Glucagon-Like Peptide 1 (1-37) (huMan, bovine, guinea pig, Mouse, rat)
- GLP-1 (1-37) (human, bovine, gp, mouse, rat)
- ANTI-GLP1 (CENTER) antibody produced in rabbit
- GATA-like protein 1
- H-HIS-ASP-GLU-PHE-GLU-ARG-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH
- GLP-1 USP/EP/BP
- Rat GLP-I(1-37)
- GLP-1, 5mg/vial
- GLP-1 (1-37) (human)
- 87805-34-3
- C186H275N51O59
- Cytokines, Growth Factors and Hormones
- Hormones
- Other Protein/Peptide Hormones
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- Glucagon receptor and related
- hormones
