DRB
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- CAS-Nr.
- 53-85-0
- Englisch Name:
- DRB
- Synonyma:
- DRB;DBR;NSC 401575;DRB USP/EP/BP;DRB (Benzimidazole);dichlororibofuranosylbenzimidazole;5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE;Dichlorobenzimidazoleribofuranoside;5,6-dichloro-1-β-D-ribobenzimidazole;5,6-dichlorobenzimidazoleriboside(drb)
- CBNumber:
- CB0367110
- Summenformel:
- C12H12Cl2N2O4
- Molgewicht:
- 319.14
- MOL-Datei:
- 53-85-0.mol
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DRB Eigenschaften
- Schmelzpunkt:
- 222-224°C
- Siedepunkt:
- 606.2±65.0 °C(Predicted)
- Dichte
- 1.5917 (rough estimate)
- Brechungsindex
- 1.6200 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- Soluble in DMSO (up to 20 mg/ml)
- pka
- 13.23±0.70(Predicted)
- Aggregatzustand
- White solid
- Farbe
- White
- Wasserlöslichkeit
- Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers.
- maximale Wellenlänge (λmax)
- 296nm(lit.)
- BRN
- 39123
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChIKey
- XHSQDZXAVJRBMX-AYLPWXGPSA-N
- CAS Datenbank
- 53-85-0
DRB Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White Solid
Verwenden
DRB is an inhibitor of RNA synthesis (causes premature termination of transcription).
Biochem/physiol Actions
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive. It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification. It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.
DRB Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
DRB Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 96)Lieferanten
53-85-0()Verwandte Suche:
- 5,6-DICHLOROPURINE-1-BETA-D-RIBOFURANOSYL-H-BENZIMIDAZOLE
- 5,6-DICHLORO-1-BETA-D-RIBOFURANOSYLBENZIMIDAZOLE
- 5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazol
- 5,6-dichlorobenzimidazoleriboside(drb)
- Dichlorobenzimidazoleribofuranoside
- dichlororibofuranosylbenzimidazole
- 5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole
- 5,6-Dichloropurine-1-b-D-ribofuanosyl-H-benzimidazole
- DBR,5,6-Dichlorobenzimidazole1-b-D-ribofuranoside
- 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole
- 5,6-dichlorobenzimidazole 1-β-d-ribofuranoside
- 5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside
- 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-Dichlorobenzimidazole riboside, DRB
- 5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE 98%
- 5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE (DRB)98%
- 5,6-Dichloropurine-1--D-ribofuanosyl-H-benzimidazole
- DBR, 5,6-Dichlorobenzimidazole 1--D-ribofuranoside
- 5,6-Dichlorobenzimidazole-1-β-D-ribofuranoside ,98%
- 1-β-D-Ribofuranosyl-5,6-dichlorobenziMidazole
- NSC 401575
- 4,5-dichloro-2-(3-methylbenzyl)pyridazin-3(2h)-one
- 5,6-DICHLOROBENZIMIDAZOLE-1-BETA-D-RIBOFURANOSIDE
- 5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE
- 5,6-DICHLORO-BETA-D-RIBOFURANOSYL-BENZIMIDAZOLE
- DRB (Benzimidazole)
- DRB
- DBR
- DRB USP/EP/BP
- (2R,3R,4S,5R)-2-(5,6-Dichloro-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- 5,6-DICHLOROBENIMIDAZOLE-1-B-D- RIBOFURANOSIDE
- 5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
- 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem
- 5,6-Dichlororibofuranosylbenzimidazole
- 5,6-Dichlorobenzimidazole1-β-D-Ribofuranoside>
- 5,6-Dichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole
- 1H-Benzimidazole, 5,6-dichloro-1-β-D-ribofuranosyl-
- 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
- 5,6-Dichlorobenzimidazole riboside,DRB,inhibit,Inhibitor,CDK,Cyclin dependent kinase
- 5,6-Dichlorobenzimidazole riboside(DBR)
- 1H-Benzimidazole,5,6-dichloro-1-b-D-ribofuranosyl-
- 5,6-dichloro-1-β-D-ribobenzimidazole
- ,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
- 53-85-0
- C12H12Cl2N2O4
- DNA-RNA Transcription Regulators
- Gene Regulation and Expression
- Monosaccharides
- Specialty Synthesis
- BioChemical
- Cell Biology
- Carbohydrate Synthesis
- Cell Signaling and Neuroscience
- Bases & Related Reagents
- Inhibitors
- Nucleotides
