ChemicalBook > Produktkatalog >Bio- und Chemieingenieurwesen >Inhibitoren >Epigenetik >DNA-Methyltransferase-Inhibitoren >RG108

RG108

48208-26-0

CAS-Nr.: 48208-26-0

Englisch Name:: RG108

Synonyma:: 108;CS-1518;RG108 >98%;RG108/RG-108;RG108 USP/EP/BP;N-Phthalyl-L-tryptophan;N-Phthaloyl-L-tryptophan;N-Phthalyl-L-tryptophan>DNA Methyltransferase Inhibitor;RG-108;RG 108;N-PHTHALYL-L-TRYPTOPHAN

CBNumber:: CB0972112

Summenformel:: C19H14N2O4

Molgewicht:: 334.33

MOL-Datei:: 48208-26-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 144

RG108 Eigenschaften

Schmelzpunkt:: 192-194℃

Siedepunkt:: 606.0±50.0 °C(Predicted)

Dichte: 1.502±0.06 g/cm3(Predicted)

storage temp.: -20°C

Löslichkeit: DMSO: >10mg/mL

pka: 3.62±0.10(Predicted)

Aggregatzustand: powder

Farbe: yellow

Sensitive: Light Sensitive

Stabilität:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

CAS Datenbank: 48208-26-0

Sicherheit

WGK Germany	3
HS Code	2933.99.9701

RG108 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

RG108 has been used:

in reprogramming and increasing cell plasticity of primary multipotent mesenchymal stromal cells (MMSC)
as an inhibitor of DNA methyltransferase (DNMTi) in human retinal pigment epithelial ARPE-19 cells
as a DNA methyltransferase inhibitor in C33A2 cells to test its effect on papillomavirus late gene expression (HPV16)

Allgemeine Beschreibung

RG108, a non-nucleoside analog is also called [2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl) propanoic acid.

Biologische Aktivität

Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.

RG108 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

RG108 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 144)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28098	58
AFINE CHEMICALS LIMITED	0571-85134551 18958018566;	info@afinechem.com	China	15377	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

48208-26-0()Verwandte Suche:

2-(β-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-on

(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
RG108/RG-108
(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid
N-Phthaloyl-L-tryptophan
1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-
N-Phthaloyl-L-tryptophan (S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid
DNA Methyltransferase Inhibitor
N-Phthalyl-L-tryptophan
RG108 >98%
RG108/DNA Methyltransferase Inhibitor/N-Phthalyl-L-tryptophan
2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
CS-1518
RG-108;RG 108;N-PHTHALYL-L-TRYPTOPHAN
N-Phthalyl-L-tryptophan>
108
RG108 USP/EP/BP
1H-Indole-3-propanoicacid, a-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-,(aS)-
48208-26-0
Inhibitors
DNA Methyltransferase Inhibitor
Epigenetics