Pengitoxin

Pengitoxin Struktur
7242-04-8
CAS-Nr.
7242-04-8
Bezeichnung:
Pengitoxin
Englisch Name:
Pengitoxin
Synonyma:
Pentaacetate;pentaacetylgitoxin;Card-20(22)-enolide, 16-(acetyloxy)-3-[(O-3,4-di-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)-
CBNumber:
CB11118358
Summenformel:
C51H74O19
Molgewicht:
991.12
MOL-Datei:
7242-04-8.mol

Pengitoxin Eigenschaften

Schmelzpunkt:
151-155°
alpha 
D20 +14.0 ±1.5° (c = 1.6 in pyridine)
Siedepunkt:
742.94°C (rough estimate)
Dichte
1.1187 (rough estimate)
Brechungsindex
1.6500 (estimate)
Wasserlöslichkeit
11.89mg/L(temperature not stated)

Sicherheit

Toxizität LD50 in mice (mg/kg): 6.4 i.p.; in rats (mg/kg): 21.0 i.v. (Foerster)

Pengitoxin Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Pengitoxin,Shanghai Lansheng

Manufacturing Process

Gitoxin is isolated from leaves of Digitalis purpurea L. genus Scrofphulariaceae.
10.0 g pure gitoxin are boiled under reflux with 1 L pure acetic anhydride. Gitoxin thereby goes into solution in the course of 1 h. The boiling is discontinued after 1 h and the acetic anhydride distilled off in a vacuum as completely as possible. After taking up the oily residue with 500 ml chloroform, the solution is successively washed with 200 ml of 2 N potassium bicarbonate solution, 0.1 N hydrochloric acid and water. After drying the chloroform solution with anhydrous sodium sulfate, the chloroform is first distilled off over an open flame and then on a water bath at 40°C in a vacuum, a substantially crystalline residue thereby being obtained. The 12.8 g of crude product obtained are recrystallized from 12 times the amount of a mixture of pyridine, methanol and water (25:10:65) to give rhombic crystals, melting point 151°-155°C.

Therapeutic Function

Cardiotonic

Pengitoxin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pengitoxin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
2A PharmaChem USA --
sales@2apharmachem.com United States 6148 39
3B Scientific Corporation --
sales@3bsc.com United States 6744 47

  • pentaacetylgitoxin
  • Pentaacetate
  • Card-20(22)-enolide, 16-(acetyloxy)-3-[(O-3,4-di-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)-
  • 7242-04-8
  • 7242-04-08
  • C51H74O19
Copyright 2019 © ChemicalBook. All rights reserved