TIC10

1616632-77-9

CAS-Nr.: 1616632-77-9

Englisch Name:: TIC10

Synonyma:: imipridone;TIC10;ONC201;CS-2579;ONC201,TIC10;dordaviprone;TIC-10 (ON201);TIC10(ONC-201);TIC 10 active isomer;TIC10 (imipridone, ONC201, NSC350625)

CBNumber:: CB12711459

Summenformel:: C24H26N4O

Molgewicht:: 386.49

MOL-Datei:: 1616632-77-9.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 94

TIC10 Eigenschaften

Siedepunkt:: 559.7±60.0 °C(Predicted)

Dichte: 1.24±0.1 g/cm3(Predicted)

storage temp.: Sealed in dry,Store in freezer, under -20°C

Löslichkeit: Soluble in DMSO (up to 25 mg/ml with warming).

pka: 6.38±0.20(Predicted)

Aggregatzustand: solid

Farbe: Pale yellow

Stabilität:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

Sicherheit

TIC10 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 μM in a p53-independent manner. It is orally active, stable, and crosses the blood-brain barrier. The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a. TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.

TIC10 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

TIC10 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 94)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

ONC201,TIC10
TIC-10 (ON201)
2,4,6,7,8,9-Hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
TIC10(ONC-201)
TIC 10 active isomer
ONC201
7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-on
TIC10
TIC10 (imipridone, ONC201, NSC350625)
Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-
CS-2579
(11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetraazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one)
ONC201; ONC 201; ONC-201; NSC350625; NSC-350625; NSC 350625; TIC10; TIC 10; TIC-10; TRAIL INDUCING COMPOUND 10; IMIPRIDONE
imipridone
dordaviprone
1616632-77-9
APL
APIS