Erythromycin-2'-propanoat-dodecylsulfat
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- CAS-Nr.
- 3521-62-8
- Bezeichnung:
- Erythromycin-2'-propanoat-dodecylsulfat
- Englisch Name:
- Erythromycin Estolate
- Synonyma:
- Phtalic anhydride;ilosone;Eriscel;Togiren;Eupragin;eromycin;Erytrarco;eritroger;Estomicina;NSC 263364
- CBNumber:
- CB1286137
- Summenformel:
- C52H97NO18S
- Molgewicht:
- 1056.39
- MOL-Datei:
- 3521-62-8.mol
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Erythromycin-2'-propanoat-dodecylsulfat Eigenschaften
- Schmelzpunkt:
- 135-140°C dec.
- Siedepunkt:
- 743℃
- Dichte
- 1.0053 (rough estimate)
- Brechungsindex
- 1.6550 (estimate)
- Flammpunkt:
- >110°(230°F)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Löslichkeit
- chloroform: soluble4.0ML, clear, colorless (200 mg + 4.0 mL Chloroform)
- pka
- 6.9(at 25℃)
- Farbe
- white
- Wasserlöslichkeit
- Freely soluble in organic solvents, practically insoluble in water
/n
- Sensitive
- Light Sensitive
- CAS Datenbank
- 3521-62-8
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn,Xi |
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| R-Sätze: |
22-42/43-36/37/38 |
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| S-Sätze: |
22-36-26 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
KF5775000 |
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| HS Code |
29419000 |
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| Toxizität |
LD50 orally in rats: >5000 mg/kg (Goldenthal) |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P261, P285, P304+P341, P342+P311,P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
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Erythromycin-2'-propanoat-dodecylsulfat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Erythromycin estolate was synthesized by the Lilly Research Laboratories in 1959. It shows a higher and longer lasting serum level than erythromycin and the other esters, ethylsuccinate and stearate, when administered orally. This antibiotic is stable against gastric acids, and after oral absorption it is hydrolyzed gradually into erythromycin. Long-term usage of erythromycin estolate is toxic to the liver. Erythromycin ethylsuccinate [41342-53-4], (C43H75NO16, Mr 862.07) and erythromycin stearate [643-22-1] (C37H67NO13 · C18H36O2, Mr 1018.43) also have been used orally, and erythromycin lactobionate [3847-29-8] (C37H67NO13 · C12H22NO12, Mr 1092.25) has been used by intravenous administration and opthalmic topical application
Chemische Eigenschaften
Long Needles
Weltgesundheitsorganisation (WHO)
Erythromycin estolate, a macrolide antibiotic, was introduced in
1958 for the treatment of gram-positive infections. By the early 1970s its use had
been associated with a higher incidence of hepatic toxicity than that seen with
other salts and esters of erythromycin. This led to its withdrawal by some
regulatory authorities whereas others required the addition of a warning in the
product information. Evidence that the estolate ester is more hepatotoxic than
other salts or esters has subsequently been disputed. It has been claimed to be the most effective ester for treatment of Legionnaire's disease and preparations remain
widely available.
(Reference: (BMJOAE) British Medical Journal, 286, 1954, 1983)
Allgemeine Beschreibung
Erythromycin estolate, erythromycin propionate lauryl sulfate(Ilosone), is the lauryl sulfate salt of the 2＇-propionateester of erythromycin. Erythromycin estolate is acid stableand absorbed as the propionate ester. The ester undergoesslow hydrolysis in vivo. Only the free base binds to bacterialribosomes. Some evidence, however, suggests that theester is taken up by bacterial cells more rapidly than thefree base and undergoes hydrolysis by bacterial esteraseswithin the cells. The incidence of cholestatic hepatitis is reportedlyhigher with the estolate than with other erythromycinpreparations.
Erythromycin estolate occurs as long needles that aresparingly soluble in water but soluble in organic solvents. administration for the treatment of serious infections,such as Legionnaires disease, or when oral administrationis not possible. Solutions are stable for 1 week whenrefrigerated.
Erythromycin-2'-propanoat-dodecylsulfat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-(4-chlorop henyl)-4，5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyr role-3-carbonitrile
ROKITAMYCIN
Zopiclon
4,4'-[(2β,3α,5α,16β,17β)-3,17-Bis(acetoxy)androstan-2,16-diyl]bis[1,1-dimethylpiperazinium]dibromid
Disperse Yellow HG
DL-Histidin
L-Isoleucin
Ozagrel
2-Cyan-N-[(ethylamino)carbonyl]acetamid
disodium 5-((4-acetylamino-2-sulphophenyl)azo)-6-amino-4-hydroxynaphthalene-2-disulphonate
azafenidin
DL-Tyrosin
polybenzo conductive polymer materials
PGA and its copolymer
Acetylcholinchlorid
Nilvadipine
3,4,5,6-Tetrahydro-N-(hydroxymethyl)phthalimid
Erythromycin-2'-propanoat-dodecylsulfat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 377)Lieferanten
3521-62-8(Erythromycin-2'-propanoat-dodecylsulfat)Verwandte Suche:
- erythromycinpropionatelaurylsulfate
- ERYTHROMYCIN ESTOLATE
- ERYTHROMYCIN 2'-PROPANOATE DODECYL SULFATE SALT
- ERYTHROMYCIN 2'-PROPIONATE DODECYL SULFATE
- ERYTHROMYCIN 2-PROPIONATE DODECYL SULFATE
- [4-DIMETHYLAMINO-2-[[14-ETHYL-7,12,13-TRIHYDROXY-4-(5-HYDROXY-4-METHOXY-4,6-DIMETHYL-OXAN-2-YL)OXY-3,5,7,9,11,13-HEXAMETHYL-2,10-DIOXO-1-OXACYCLOTETRADEC-6-YL]OXY]-6-METHYL-OXAN-3-YL] PROPANOATE, 1-SULFOOXYDODECANE
- Erythromycin Estolate BP
- Erythromycin Estolate I.P/Bp
- ERYTHROMYCIN ESTOLATE USP(CRM STANDARD)
- ERYTHROMYCIN ESTOLATE EPE(CRM STANDARD)
- ErythromycinEstolate-Bp/Ep/Usp
- ErythromycinEstolateErythromycinEstolateBp/Usp
- ERYTHROMYCINESTOLATE,USP
- Eriscel
- Erythromycin, 2'-propionate, dodecyl sulfate (salt) (8CI)
- Erythromycin, monopropanoate (ester), dodecyl sulfate (salt)
- Erythromycin, monopropionate (ester), compd. with monododecyl sulfate (1:1)
- Erythromycin, propionate, compd. with dodecyl sulfate (7CI)
- Erytrarco
- Estomicina
- Eupragin
- Lubomycine B
- Marcoeritrex
- NSC 263364
- Propiocine Enfant
- Propionic acid, 2'-ester with erythromycin, dodecyl sulfate salt (6CI)
- Propionylerythromycin lauryl sulfate
- erythromycinpropionyllaurylsulfate
- lauromicina
- laurylsulfatepropionylerythromycinester
- neo-erycinum
- roxomicina
- stellamicina
- Sulfuric acid, monododecyl ester, compd. with erythromycin 2'-propanoate (1:1) (9CI)
- Sulfuric acid, monododecyl ester, compd. with erythromycin 2'-propionate (1:1) (8CI)
- Togiren
- ERYTHROMYCINPROPIONATELAURYLSULPHATE
- [4-Dimethylamino-2-[[(3R,4S,6R,7R,9R,11R,12R,13R,14R)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradec-6-yl]oxy]-6-methyl-oxan-3-yl] propanoate 1-sulfooxydodecane
- Erythromycin estorate
- Erythro* Estolate
- Erythromycin 2'-prop
- Erythromycin Estolate (200 mg)
- ErythroMycin Estolate API
- eritroger
- eromycin
- erythromycin,propionate(ester),compd.withmonododecylsulfate(1:1)
- erythromycin5-(3-propionate)dodecylsulfate
- erythromycinpropionate,compd.withdodecylsulfate
- Relying on erythromycin
- Erytromycin ,Ilosone, Lauromycin, Laurylin, Propiocin, Ritromin
- Erythromycin estolate CRS
- (2S,3R,4S,6R)-4-(Dimethylamino)-2-(((3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-2,10-dioxooxacyclotetradecan-6-yl)oxy)-6-methyltet
- Erythromycin Estolate USP/EP/BP
- Erythromycin Estolate (1243002)
- propanoic acid [(2S,3R,4S,6R)-4-(dimethylamino)-2-[[(3R,4S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[[(2S,4S,5R,6R)-5-hydroxy-4-methoxy-4,6-dimethyl-2-oxanyl]oxy]-3,5,7,9,11,13-hexameth
- Erythromycin Estolate Usp30
- Phtalic anhydride
- ilosone
