3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

913830-15-6

CAS-Nr.: 913830-15-6

Englisch Name:: 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

Synonyma:: NS 9283;NS-9283;NS9283;NS 9283;NS-9283;NS9283;3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile;3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile;Benzonitrile, 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-;NS9283,Inhibitor,Nicotinic acetylcholine receptors,nAChR,inhibit

CBNumber:: CB13049683

Summenformel:: C14H8N4O

Molgewicht:: 248.24

MOL-Datei:: 913830-15-6.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 38

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Eigenschaften

Siedepunkt:: 469.9±55.0 °C(Predicted)

Dichte: 1.37±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 3 mg/ml; Ethanol: Partially soluble

Aggregatzustand: A crystalline solid

pka: 1.40±0.12(Predicted)

Sicherheit

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NS 9283 is a positive allosteric modulator of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs (EC₅₀ = 4 μM). In vivo, NS 9283 potentiates ABT-594 analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia, paw skin incision post-operative pain, and monoiodoacetate-induced osteoarthritis. It reduces nicotine, but not sucrose, self-administration and reinstatement in rats when administered at a dose of 3.5 mg/kg.

Verwenden

NS 9283 is a positive allosteric modulator of α4β2 receptor affecting the potency of acetylcholine (Ach) related events. This has been linked to affect on everyday brain function including cognitive function and pain alleviation.

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 38)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
Shanghai JiYi Biotechnology Co. Ltd.	13621943973	sales@shjiyipharmatech.com	China	1166	55
D&C Chemicals	+86-21-58447131	1724405207@qq.com	China	472	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai Biopharmaleader Co., Ltd.	+86 18721201413	sales@biopharmaleader.com	China	1720	58

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
NS 9283
3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
NS 9283;NS-9283;NS9283
NS-9283;NS9283
Benzonitrile, 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-
NS9283,Inhibitor,Nicotinic acetylcholine receptors,nAChR,inhibit
913830-15-6