8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
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- CAS-Nr.
- 666816-98-4
- Englisch Name:
- 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
- Synonyma:
- 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine;8-broMo-7-(but-2-yn-1-yl)-3-Methyl-1H-purine-2,6(3H,7H)-dione;8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione;3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine 8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione;Linagliptin INT1;8-BROMO-7-(BUT-2-YNYL);Linagliptin Impurity 36;Linagliptin Impurity 73;Iinagliptin Intermediate2;Linagliptin interMediateC
- CBNumber:
- CB22538943
- Summenformel:
- C10H9BrN4O2
- Molgewicht:
- 297.11
- MOL-Datei:
- 666816-98-4.mol
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8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione Eigenschaften
- Schmelzpunkt:
- 285 °C
- Dichte
- 1.71
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- powder to crystal
- pka
- 8.91±0.70(Predicted)
- Farbe
- White to Almost white
- LogP
- 1.25 at 20℃
- CAS Datenbank
- 666816-98-4
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H412 |
Schädlich für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 3 |
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P273, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White powder
Synthese
8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione (2.450 g, 10 mmol),1-bromo-2-butyne (1.596 g, 12 mmol), Sodium carbonate (1.590 g, 15 mmol), and 20mL of acetone was added to a 100mL flask. The reaction system was heated to 40 ° C, and the reaction was stirred for 4h. After the reaction was cooled to room temperature, suction filtration was performed, and the filter cake was washed with methanol to obtain a crude product as a pale yellow solid. The crude product was reconstituted with dichloromethane and cyclohexane. Yield 2.912 g of 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione. The yield was 98%, and the purity was 99.9%.
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 401)Lieferanten
666816-98-4()Verwandte Suche:
- 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
- 8-broMo-7-(but-2-ynyl)-3-Methyl-3,7-dihydropurine-2,6-dione
- 3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine
- 8-broMo-7-but-2-yn-1-yl-3-Methyl-3,7-dihydro-1H-purine-2,6-dione
- 8-BroMo-7-(2-butyn-a-yl)-3,7-dihydro-3-Methyl-1-1H-purine-2,6-dione
- Linagliptin interMediateC
- (R)-tert-butyl 1-(7-(but-2-ynyl)-3-Methyl-1-((4-Methylquinazolin-2-yl)Methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-ylcarbaMate
- 3-Methyl-7-(2-butin-1-yl)-8-broMoxanthine
- 1H-Purine-2,6-dione, 8-broMo-7-(2-butynyl)-3,7-dihydro-3-Methyl-
- Iinagliptin Intermediate2
- Linagliptin INT1
- 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione/3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine
- 8-Bromo-7-(2- butynyl)-3,7-dihydro- 3-methyl-1H-pur ine-2,6-dion
- 8-BROMO-7-(BUT-2-YNYL)
- 8-bromo-7-(but-2-ynyl)-3-methyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione
- 8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H
- 8- bromo -7-(2- butyne)-3- methyl xanthine
- 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2
- 8-bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-indole-2,6-dione
- Linagliptin Impurity 36
- 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dion
- 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine >
- 1H-Purine-2,6-dione, 8-bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-
- 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione
- LINAGLIPTIN CAS 668270-12-0 INTERMEDIATES
- 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione USP/EP/BP
- (2-(chloromethyl)-4-methylquinazoline)，8-bromo-7-(but-2-ynyl)-3-methyl-1H- purine-2,6(3H,7H)-dione
- Linagliptin intermediates，8-bromo-7-(but-2-ynyl)-3-methyl-1H- purine-2,6(3H,7H)-dione
- Linagliptin Impurity 73
- 8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1Hpurin-2,6(3H,7H)-dione
- 8-bromo-7-but-2-yn-1-yl-3-methyl-3,7-dihydro-1H-purine-2,6-d...
- 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine]Q: What is
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine] Q: What is the CAS Number of
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine] Q: What is the storage condition of
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine]
- 8-BROMO-3-METHYL-7-BUT-2-YNYL XANTHINE
- 8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione
- 8-broMo-7-(but-2-yn-1-yl)-3-Methyl-1H-purine-2,6(3H,7H)-dione
- 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine
- 3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine 8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione
- 8-Bromo-7-But-2-Ynyl-3-Methyl-Purine-2,6-Dione / Linagliptin Intermediate
- Hydrazinecarbothioamide,N-(10-methoxyphenyl)-
- 8-bromo-7 -(2-butynyl) -3-methylxanthine
- 8-bromo-3-methyl-7-(prop-1-yn-1-yl)-1H-purine-2,6(3H,7H)-dione
- 8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3
- Linagliptin intermediate 8-bromo-7-but-2-yn-1-yl-3-methyl-3,7-dihydro-1H-purine-2,6-dione
- 8-Bromo-7-(2-butynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
- 666816-98-4
- 666816-98-4
