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Dacomitinib (PF299804)

Dacomitinib (PF299804) Struktur
1110813-31-4
CAS-Nr.
1110813-31-4
Englisch Name:
Dacomitinib (PF299804)
Synonyma:
Dacomitinib;PF299804;(E)-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-Methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enaMide;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide Dacomitinib (PF299804, PF299);PF299;CS-168;Dachtini;Dakotinib;dacatinib;PF-00299804
CBNumber:
CB22566418
Summenformel:
C24H25ClFN5O2
Molgewicht:
469.94
MOL-Datei:
1110813-31-4.mol
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Dacomitinib (PF299804) Eigenschaften

Schmelzpunkt:
184-187°C
Siedepunkt:
665.7±55.0 °C(Predicted)
Dichte
1.344
storage temp. 
Refrigerator
Löslichkeit
DMSO (Slightly), Methanol (Slightly, Heated)
Aggregatzustand
White solid.
pka
12.05±0.43(Predicted)
Farbe
White to Pale Yellow
CAS Datenbank
1110813-31-4
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
HS Code  29335990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Dacomitinib (PF299804) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The epidermal growth factor receptors (EGFR), whose members include ErbB1 (HER1), ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4), are receptor tyrosine kinases that are often over-expressed in cancer. PF-299804 is a second generation pan-ErbB receptor tyrosine kinase inhibitor (IC50s = 6, 45.7, and 73.7 nM for ErbB1, ErbB2, and ErbB4, respectively) that irreversibly binds to the ATP site in the catalytic domains of ErbB receptors. At 15 mg/kg, it demonstrates antitumor activity ranging from delay in tumor growth to complete regression in various tumor xenograft models expressing either wild-type ErbB or mutant ErbB family members that show resistance to first generation ErbB kinase inhibitors.

Verwenden

PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively.

Definition

ChEBI: A member of the class of quinazolines that is 7-methoxyquinazoline-4,6-diamine in which the amino group at position 4 is substituted by a 3-chloro-4-fluorophenyl group and the amino group at position 6 is substituted by an (E)-4-(piperidin 1-yl)but-2-enoyl group.

Dacomitinib (PF299804) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Dacomitinib (PF299804) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 341)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177
 peter@yan-xi.com China 5993 58
shandong perfect biotechnology co.ltd 		+86-53169958659; +8618596095638
 sales@sdperfect.com China 294 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152
 Mandy@hangyubiotech.com China 11013 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858
 daisy@anhuiruihan.com China 994 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806
 sales@capotchem.com China 29797 60
Shanghai Bojing Chemical Co.,Ltd. 		+86-86-02137122233 +8613795318958
 bj1@bj-chem.com China 298 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
 fandachem@gmail.com China 9347 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58

1110813-31-4()Verwandte Suche:

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron
  • PF-00299804-03
  • PF-00299804
  • DacoMitinib (PF-00299804)
  • DacoMitinib,PF299804
  • DacoMitinib (PF299804,PF-00299804)
  • PF299804;DACOMITINIB
  • DacoMitinib (PF299804, PF299)
  • (E)-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-Methoxyquizolin-6-yl)-4-(piperidin-1-yl)but-2-eMide
  • dacomitinib (pan-HER inhibitor)
  • (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide
  • Dacomitinib, >=98%
  • 2-Butenamide,N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-, (2E)-
  • PF299
  • PF299804;(E)-N-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-METHOXYQUINAZOLIN-6-YL)-4-(PIPERIDIN-1-YL)BUT-2-ENAMIDE
  • (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
  • PF299804 (Dacomitinib, PF299)
  • PF299804, PF299)
  • PF-299804 (Dacomitinib,PF-00299804)
  • CS-168
  • PF299804; DACOMITINIB; PF-00299804;PF-299804;PF 299804
  • Dacomitinib, 98%, a potent irreversible ErbB inbibitor
  • Dacomitinib (USAN/INN)
  • Dacomitinib [USAN]
  • Dacomitinib Dacomitinib
  • Dacomitinib-D10
  • Dacomitinib (PF299804) USP/EP/BP
  • Dacomitinib dihydrochloride salt
  • Dacomitinib D10 dihydrochlorideQ: What is Dacomitinib D10 dihydrochloride Q: What is the CAS Number of Dacomitinib D10 dihydrochloride
  • Dacomitinib D3
  • Dacomitinib D5
  • Dacomitinib
  • (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide Dacomitinib (PF299804, PF299)
  • PF299804
  • (E)-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-Methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enaMide
  • Dachtini
  • Dacomitinib free base
  • Dacomitinib / PF 00299804-03
  • Dakotinib
  • dacatinib
  • 1110813-31-4
  • C24H25ClFN5O2
  • Inhibitors
  • Anti-cancer&immunity
  • API
  • API
  • 1
  • APIs
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