N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide

1052147-86-0

CAS-Nr.: 1052147-86-0

Englisch Name:: N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide

Synonyma:: LP21;LP-211;LP-211 >=98% (HPLC);LP-211; LP 211; LP211;1052147-86-0;N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide;1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-;LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit

CBNumber:: CB23385434

Summenformel:: C30H34N4O

Molgewicht:: 466.62

MOL-Datei:: 1052147-86-0.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 38

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Eigenschaften

Siedepunkt:: 714.8±60.0 °C(Predicted)

Dichte: 1.17±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO:100.0(Max Conc. mg/mL);214.3(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);107.15(Max Conc. mM)

pka: 15.39±0.46(Predicted)

Aggregatzustand: solid

Farbe: clear white to light brown

Sicherheit

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor used in pharmacological studies which showed that it underwent metabolic breakdown to RA-7 and showed pharmacological activities such as induced hypothermia in mice and showed optimal pharmacokinetics in rats.LP-211 is also a drug analogue of piperazinehexanamide exhibiting 5-HT7 receptor affinity.

Biochem/physiol Actions

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 38)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4153	55
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	27322	60
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62

LP-211
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
LP-211; LP 211; LP211;1052147-86-0
LP21
LP-211 >=98% (HPLC)
LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit
1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-
1052147-86-0
API