3-Aminopropan-1-sulfonsaeure
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- CAS-Nr.
- 3687-18-1
- Bezeichnung:
- 3-Aminopropan-1-sulfonsaeure
- Englisch Name:
- 3-Amino-1-propanesulfonic acid
- Synonyma:
- HOMOTAURINE;3-AMINOPROPANE-1-SULFONIC ACID;3 APS;NC 758;TRAMIP;Alzhemed;NSC 77071;Homotaurin;TRAMIPROSATE;3-Sulfopropylamine
- CBNumber:
- CB2741107
- Summenformel:
- C3H9NO3S
- Molgewicht:
- 139.17
- MOL-Datei:
- 3687-18-1.mol
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3-Aminopropan-1-sulfonsaeure Eigenschaften
- Schmelzpunkt:
- 293 °C (dec.)(lit.)
- Dichte
- 1.202 (estimate)
- Brechungsindex
- 1.5130 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- Water (Slightly)
- Aggregatzustand
- Crystalline Powder
- pka
- 1.06±0.50(Predicted)
- Farbe
- White to slightly blue
- LogP
- -4.555
- CAS Datenbank
- 3687-18-1(CAS DataBase Reference)
3-Aminopropan-1-sulfonsaeure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.
Chemische Eigenschaften
White Powder
Verwenden
3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.
Biologische Aktivität
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo .
3-Aminopropan-1-sulfonsaeure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Aminopropan-1-sulfonsaeure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 346)Lieferanten
3687-18-1(3-Aminopropan-1-sulfonsaeure)Verwandte Suche:
- aminopropanesulfonicacid,3-aminopropanesulfonicacid
- 3-AMINO-1-PROPANESULFONIC ACID
- 3-AMINOPROPANESULFONIC ACID
- 3 APS
- 3-aminopropane-1-sulphonic acid
- TRAMIPROSATE
- 3-Aminopropiosulfonic Acid
- 3-Sulfopropylamine
- Alzhemed
- NC 758
- NSC 77071
- 1-Propanesulfonic acid, 3-amino-
- 3-AMino-1-propanesulfonic acid (HoMotaurine)
- AcaMprosate Related CoMpound A
- 3-AMino-1-propanesulfonic acid 97%
- Homotaurin
- 3-Aminopropan-1-sulfonsure
- 3-Amino-1-propanesulfonic acid,95%
- 3-Amino-1-propanesulfonic acid,3APS, Homotaurine, Tramiprosate
- HoMotaurine (3-AMinopropanesulfonic Acid)
- 3-AMino-1-propanesulfonic acid, 95% 1GR
- 3-Aminopropanesulfonate
- TRAMIP
- Acamprosate Impurity 1（Acamprosate USP RC A）
- -Amino-1-propanesulfonic acid
- Acamprosate EP Impurity A (Homotaurine)
- 3-Amino-1-propanesulfonic Acid >
- Acamprosate impurity A CRS
- 3-Aminopropane-1-sulfonic Acid (Hom
- 3-Amino-1-propanesulfonic acid ISO 9001：2015 REACH
- Acamprosate calcium EP Impurity A
- -Amino-1-propanesulfonic acid
- Acamprosate Related Compound A (3-aminopropane-1-sulfonic acid) (1000565)
- 3-Amino-1-propanesulfonic
- HOMOTAURINE
- 3-AMINOPROPANE-1-SULFONIC ACID
- Acamprosate USP Related Compound A
- 3687-18-1
- H2NCH23SO3H
- SULFONIC ACID
- Building Blocks
- Sulfonic/Sulfinic Acids
- Sulfur Compounds
- Organic Building Blocks
- Inhibitors
- Metal Isotopes
- Sulfur & Selenium Compounds
- Organic Building Blocks
- Sulfonic/Sulfinic Acids
- Sulfur Compounds
- Pharmaceutical Raw Materials
- API
