EC 3.4.15.1
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- CAS-Nr.
- 9015-82-1
- Englisch Name:
- EC 3.4.15.1
- Synonyma:
- ACE;ANGIOTENSIN CONVERTING ENZYME;ACE (HUMAN);EC 3.4.15.1;ACE (enzyme);Carboxycathepsin;Carboxypeptidase Zace2;PEPTIDYLDIPEPTIDE HYDROLASE;ACE, Peptidyl-dipeptidaseA;Dipeptidyl carboxypeptidase A
- CBNumber:
- CB3358160
- Summenformel:
- C2H5NO
- Molgewicht:
- 59.0672
- MOL-Datei:
- 9015-82-1.mol
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EC 3.4.15.1 Eigenschaften
- storage temp.
- -20°C
- Aggregatzustand
- lyophilized powder
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P261, P285, P304+P341, P342+P311,P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P284 |
Atemschutz tragen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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EC 3.4.15.1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Angiotensin converting enzyme from rabbit lung has been used:
- for measuring inhibitory effect of egg white protein hydrolysates on ACE activity by high performance liquid chromatography (HPLC)
- to measure the ACE inhibition by litchi pericarp and cooked chicken breast using hippuryl-L-histidyl-L-leucine (HHL) as substrate by reverse phase-HPLC (RP-HPLC)3 and HPLC respectively
- in releasing GPI anchored protein in vitro in few cell lines like HeLa, HEK293 and in vivo in mice sperm.
Allgemeine Beschreibung
The angiotensin-converting enzyme (ACE) is a dipeptidyl-carboxypeptidase which exists in somatic and testicular isoforms with zinc binding motif HEXXH in their active site. ACE regulates blood pressure through renin-angiotensin system. ACE elevates blood pressure by converting angiotensin I to a key vasoconstrictor angiotensin II and inhibiting a potent vasodilator bradykinin. Inhibition of ACE is a targeted therapeutic strategy for high blood pressure. Several ACE synthetic inhibitory peptides available for clinical use include captopril, enalapril and lisinopril. Currently, developing inhibitory peptides from natural food sources, or phenolic compounds from plant sources to inhibit ACE is underway. ACE plays a critical role in fertilization by releasing the proteins anchored to glycosylphosphatidylinositol (GPI) in sperm membrane.
läuterung methode
Purify ACE by fractionation on DEAE-cellulose, Ca phosphate gel chromatography, elution from Sephadex G-200 and lectin affinity chromatography. The MW varied with glycosidation and is higher by gel filtration. It contains one atom of Zn/mol and has Km values for hydrolysis of hippurylhistidinylleucine and angiotensin I of 2.3 and 0.07 mM, and turnover of 15,430 and 792 mol/min/mol at 37o, respectively. The activity is inhibited by EDTA and increased amounts of Ca ions but required Ca ions. [Das & Soffer J Biol Chem 250 6762 1975, Reviewed by Ehlers & Riordan Biochemistry 28 5311 1989.]
EC 3.4.15.1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
EC 3.4.15.1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 85)Lieferanten
9015-82-1()Verwandte Suche:
2-Methylpropylisocyanid
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')dysprosium
Tris(pentan-2,4-dionato)eisen(II)
N-Butylisocyanid
Benzylisocyanid
(Ethylenbis(nitrilomethylidyn)-2,2'-diphenolato)cobalt(II)
Angiotensin
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')europium
Aluminiumtris(2,4-pentandionato-O,O')
(p-Toluolsulfonyl)methylisocyanid
Kupfer(II)-4-oxopent-2-en-2-olat
Ethylisocyanacetat
Phenylselenol
1,1,3,3-Tetramethylbutylisocyanat
Methylisocyanacetat
(Pentan-2,4-dionato-O,O')silber
Dichloro(ethylendiamin)platin
- PEPTIDYLDIPEPTIDE HYDROLASE
- ANGIOTENSIN CONVERTING ENZYME FROMRABBIT LUNG
- ANGIOTENSIN-CONVERTIN-GAMMA-ENZYME
- ANGIOTENSIN CONVERTING ENZYME (HUMAN)
- ACE (HUMAN)
- ACE (enzyme)
- Angiotensin converting enzyme 1
- Angiotensin I-converting enzyme
- Angiotensin-1 converting enzyme
- Angiotensin-converting enzyme I
- Angiotension-converting enzyme
- Carboxycathepsin
- Carboxypeptidase Zace2
- Dipeptidyl carboxypeptidase A
- Dipeptidyl carboxypeptidase I
- Dipeptidyl serine carboxypeptidase
- ANGIOTENSIN CONVERTING ENZYME FROMPORCIN E KIDNEY
- ANGIOTENSIN-CONVERTING-ENZYME F. RABBIT LUNG, ~3 U/MG
- ACE, Peptidyl-dipeptidaseA, Peptidyldipeptide Hydrolase
- ACE, Peptidyl-dipeptidaseA
- Angiotensin Converting Enzyme from porcine kidney,ACE, Peptidyl-dipeptidaseA
- Angiotensin Converting Enzyme from rabbit lung,ACE, Peptidyl-dipeptidaseA, Peptidyldipeptide Hydrolase
- Carboxypeptidase,dipeptidyl, A
- EC 3.4.15.1
- Native Rabbit Angiotensin Converting Enzyme
- Native Rat Angiotensin Converting Enzyme
- Native Porcine Angiotensin Converting Enzyme
- Recombinant Human CD143/ACE Protein, His Tag
- ANGIOTENSIN CONVERTING ENZYME
- ACE
- 9015-82-1
- BioChemical
- Biochemicals and Reagents
- Proteolytic Enzymes
- Proteolytic Enzymes and Substrates
- Enzymes, Inhibitors, and Substrates
