Zaltoprofen Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Zaltoprofen is a potent non-steroidal antiinflammatory drug (NSAID) with analgesic
activity. In rats and mice, zaltoprofen is reported to be equipotent or superior to other NSAlDs
in bradykinin-induced pain, acetic acid-induced writhing, carrageenan-induced hyperalgesia,
and in several other experimental models of analgesia. It acts by selectively suppressing the
production of prostaglandins at the inflammatory site and not in other organs such as stomach
and kidney, therefore, has remarkably low gastric side effects that are associated with
conventional antiinflammatory agents.
Chemische Eigenschaften
Off-White to Pale Yellow Crystalline Solid
Verwenden
Anti-inflammatory activity resides in (S)-enantiomer
Synthese
The cyclization of 5-(1- cyanoethyl)-2-(phenylthio)phenylacetic acid in presence of polyphosphoric acid at 120 ℃ gives 2-(10-oxo-10,11-dihydrodibenzo[b,f ]thiepin- 2-yl)propionitrile, which is then hydrolyzed with KOH in refluxing ethanol – water to zaltoprofen.
Zaltoprofen Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
