DDD85646

1215010-55-1

CAS-Nr.: 1215010-55-1

Englisch Name:: DDD85646

Synonyma:: DDD85646;DDD 85646 (DDD85646);DDD85646 Hydrochloride;2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide;Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-;African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite

CBNumber:: CB34666388

Summenformel:: C21H24Cl2N6O2S

Molgewicht:: 495.43

MOL-Datei:: 1215010-55-1.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 34

DDD85646 Eigenschaften

Schmelzpunkt:: >215°C (dec.)

Siedepunkt:: 684.3±65.0 °C(Predicted)

Dichte: 1.48±0.1 g/cm3(Predicted)

storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere

Löslichkeit: DMSO (Slightly, Heated), Methanol (Slightly)

Aggregatzustand: Solid

pka: 7.04±0.50(Predicted)

Farbe: Off-White to Yellow

Sicherheit

DDD85646 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent K_i value of 1.44 nM. T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT. It less potently inhibits growth of T. cruzi (EC₅₀ = 6.9 μM).

Verwenden

DDD85646 is a potent inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT).

DDD85646 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

DDD85646 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 34)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4604	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4153	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2993	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9767	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58

DDD85646
DDD 85646 (DDD85646)
Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-
DDD85646 Hydrochloride
African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite
2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide
1215010-55-1
C21H24Cl2N6O2S