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(S)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid

(S)-(-)-PROPRANOLOL HYDROCHLORIDE Struktur
4199-10-4
CAS-Nr.
4199-10-4
Bezeichnung:
(S)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid
Englisch Name:
(S)-(-)-PROPRANOLOL HYDROCHLORIDE
Synonyma:
S-PROPANOLOL;S-(-)-PROPANOLOL HCL;S(-)-PROPRANOLOL HCL;l-Propranolol chlorhydrate;l-Propranolol hydrochloride;(S)-PROPRANOLOL HYDROCHLORIDE;Levopropranolol hydrochloride;L-(-)-Propranolol hydrochloride;2S-(-)-PROPANOLOL HYDROCHLORIDE;(S)-(-)-PROPRANOLOL HYDROCHLORIDE
CBNumber:
CB4455695
Summenformel:
C16H22ClNO2
Molgewicht:
295.8
MOL-Datei:
4199-10-4.mol
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(S)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid Eigenschaften

Schmelzpunkt:
193-195 °C(lit.)
storage temp. 
2-8°C
Löslichkeit
ethanol: 10 mg/mL
Aggregatzustand
powder
Optische Aktivität
[α]25/D 25.5°, c = 1.0 in ethanol(lit.)
Wasserlöslichkeit
Soluble to 100 mM in water
BRN 
3574966
InChIKey
ZMRUPTIKESYGQW-UQKRIMTDSA-N
CAS Datenbank
4199-10-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher Xn
R-Sätze: 20/21/22
S-Sätze: 36
WGK Germany  3

(S)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

(S)-(-)-Propranolol is the active enantiomer of propranolol, a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. It is also a non-specific serotonin receptor antagonist. Propanolol was one of the first β-adrenergic receptor blockers to be widely used in clinical practice for the treatment of hypertension, angina pectoris, and cardiac ischemia.

Chemische Eigenschaften

(S)-(-)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride

Verwenden

The S-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

Biologische Aktivität

More active enantiomer of the β -adrenoceptor antagonist propranolol ((RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride ).

läuterung methode

The (+)-salt is the active isomer which blocks isoprenaline tachycardia and is a -adrenergic blocker. [Leclerc et al. Trends Pharmacol Sci 2 18 1981, Howe & Shanks Nature 210 1336 1966.]

(S)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(S)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 92)Lieferanten
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4199-10-4((S)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid)Verwandte Suche:

(R)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid Dexpropranolol (±)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid [2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid (S)-[2-Hydroxy-3-(naphthyloxy)propyl]isopropylammoniumchlorid Propranolol Ethyl-1-naphthylether 3-(Isopropylamino)propan-1,2-diol
  • 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (2S)- (9CI)
  • 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (S)-
  • L-(-)-Propranolol hydrochloride
  • l-Propranolol chlorhydrate
  • l-Propranolol hydrochloride
  • S-(-)-1-Isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride
  • S-PROPANOLOL
  • (S)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride
  • (S)-(-)-1-(1-Methylethylamino)-3-naphthalen-1-yloxy-propan-2-ol hydrochloride
  • (2S)-1-(1-Naphtyloxy)-3-(isopropylamino)-2-propanol·hydrochloric acid
  • (2S)-1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol hydrochloride
  • (2S)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol hydrochloride
  • (S)-()-Propranolol hydrochloride,(S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride
  • (2S)-(-)-Propanolol Hydrochloride≥ 95% (NMR)
  • (S)-(-)-1-[(1-METHYLETHYL)AMINO]-3-(1-NAPHTHALENYLOXY)-2-PROPANOL HYDROCHLORIDE
  • (S)-1-ISOPROPYLAMINO-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE
  • S-(-)-PROPANOLOL HCL
  • S(-)-PROPRANOLOL HCL
  • (S)-(-)-PROPRANOLOL HYDROCHLORIDE
  • (S)-PROPRANOLOL HYDROCHLORIDE
  • 2S-(-)-PROPANOLOL HYDROCHLORIDE
  • (S)-[2-hydroxy-3-(naphthyloxy)propyl]isopropylammonium chloride
  • 2-Propanol, 1-(1-methylethyl)amino-3-(1-naphthalenyloxy)-, hydrochloride, (2S)-
  • (S)()Propranolol hydrochloride,(S) ( ) Propranolol hydrochloride
  • Levopropranolol hydrochloride
  • 4199-10-4
  • C16H22ClNO2
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Amino Alcohols
  • Organic Building Blocks
  • Adrenoceptor
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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