2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE

91591-63-8

CAS-Nr.: 91591-63-8

Englisch Name:: 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE

Synonyma:: 2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE;3-Cyano-2,5-dichloro-4,6-dimethylpyridine;2,5-Dichloro-4,6-dimethylnicotinonitrile 95+%;2,5-DICHLORO-4,6-DIMETHYLPYRIDINE-3-CARBONITRILE;2,5-Dichloro-4,6-diMethyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,2,5-dichloro-4,6-dimethyl-;2,5-Dichloro-4,6-dimethylpyridine-3-carbonitrile, 3-Cyano-2,5-dichloro-4,6-dimethylpyridine

CBNumber:: CB5352041

Summenformel:: C8H6Cl2N2

Molgewicht:: 201.05

MOL-Datei:: 91591-63-8.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 163

2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Eigenschaften

Schmelzpunkt:: 82 °C

Siedepunkt:: 304.6±37.0 °C(Predicted)

Dichte: 1.36

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

Aggregatzustand: solid

pka: -2.79±0.10(Predicted)

Farbe: White

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	20/21/22-36/37/38
S-Sätze:	26-36/37/39
HazardClass	IRRITANT
HS Code	2933399990

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

2,5-Dichloro-4,6-dimethyl-3-pyridinecarbonitrile, can be used for the synthesis of a selective muscarinic receptor 4 (M4) positive allosteric modulator called ML253, which is a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.

Synthese

Phosphoryl chloride (973.2g), tetramethylammonium chloride (67.3g) and compound of Preparation 2 (227.1g) were added to dichloromethane (500g). The suspension was heated to 85°C and stirred for 5 hours. Excess of phosphoryl chloride was removed by distillation in vacuo. The reaction mixture was cooled below 30 °C and diluted with dichloromethane. The resulting solution was added to water (1350g) at room temperature and stirred for 30 minutes. The lower organic phase was separate and the aqueous phase extracted with dichloromethane. The organic phases were combined, washed with water and then treated with charcoal. The charcoal was filtered and a solvent swap to heptane was performed by distillation at atmospheric pressure. The solution was filtered at 50 °C and then cooled to 30 °C. On further cooling to 0°C crystals were obtained. These were isolated by filtration, washed twice with heptane. After drying at 50°C the desired product was obtained typically at 88-91 % . The above process was repeated with a reduction in dichloromethane during crystallisation and adding some methanol. The resulting plate-like crystals were more easily transferred for subsequent use.

2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2,5-DICHLORO-4,6-DIMETHYLNICOTINAMIDE AGMWEOLWLPKJFM-UHFFFAOYSA-N

2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 163)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Fluoropharm Co., Ltd.	+86-0571-85586753; +8613336034509	sales@fluoropharm.com	China	1377	60
Win-Win Chemical CO., Limited	0086-577-64498589	sales@win-winchemical.com	CHINA	998	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4242	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Shanghai Worldyang Chemical Co.,Ltd.	,+86-21-56795779; +8613651600618	sales@worldyachem.com	China	879	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2169	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
Changzhou Carman Chemical Co., Ltd.	15061933924		CHINA	514	58

91591-63-8()Verwandte Suche:

Nicotinonitril 2-Chlornicotinonitril 2,5-Dichlorpyridin 2-Chlor-3-methylpyridin 6-Chlor-2-methylpyridin 2-Chlor-4-methylpyridin

2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
2,5-DICHLORO-4,6-DIMETHYLPYRIDINE-3-CARBONITRILE
2,5-Dichloro-4,6-dimethylpyridine-3-carbonitrile, 3-Cyano-2,5-dichloro-4,6-dimethylpyridine
2,5-Dichloro-4,6-diMethyl-3-pyridinecarbonitrile
3-Cyano-2,5-dichloro-4,6-dimethylpyridine
2,5-Dichloro-4,6-dimethylnicotinonitrile 95+%
3-Pyridinecarbonitrile,2,5-dichloro-4,6-dimethyl-
91591-63-8