Bromocriptin

Bromocriptine Struktur
25614-03-3
CAS-Nr.
25614-03-3
Bezeichnung:
Bromocriptin
Englisch Name:
Bromocriptine
Synonyma:
Parlodel;bromoergocryptine;BROMOCRITINE;bromocryptine;2-bromo-ergocryptin;Kripton;SAN 15-754;bromocriptin;,6’,18-trione;BROMOCRIPTINE
CBNumber:
CB6136426
Summenformel:
C32H40BrN5O5
Molgewicht:
654.59
MOL-Datei:
25614-03-3.mol

Bromocriptin Eigenschaften

Schmelzpunkt:
215-218° (dec)
alpha 
D20 -195° (c = 1 in methylene chloride)
Siedepunkt:
891.3±65.0 °C(Predicted)
Dichte
1.2734 (rough estimate)
Brechungsindex
1.6400 (estimate)
pka
pKa 4.90±0.05(80% MCS t = RT) (Uncertain)
Wasserlöslichkeit
2.07mg/L(temperature not stated)
CAS Datenbank
25614-03-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Toxizität An ergot alkaloid derivative that exhibits potent dopamine agonist properties, particularly at D2 dopamine receptors. Bromocriptine, like dopamine, inhibits prolactin release from the pituitary and so is used in endocrine disorders, such as hyperprolactinemia. It is also used in the treatment of Parkinson’s disease. A large “first-pass” effect is seen with bromocriptine, and peak concentrations occur about 1.5-3 h after ingestion, with a half-life of about 3 h. Nausea, vomiting, and orthostatic hypotension are among the acute adverse effects. Long-term use has been associated with dyskinesias, constipation, psychoses, digital spasm, and erythromelalgia. The LD50 in rabbits exceeds 1 g/kg, p.o., and 12 mg/kg, i.v.
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H362 Kann Säuglinge über die Muttermilch schädigen. Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P263 Kontakt während der Schwangerschaft /und der Stillzeit vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P281 Vorgeschriebene persönliche Schutzausrüstung verwenden.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P330 Mund ausspülen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Bromocriptin Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Crystals.

Verwenden

Bromocriptine, a dopaminomimetic that is a dopamine D2 receptor agonist, possesses expressed antiparkinsonian activity. It is used for treating all phases of idiopathic and postencephalic Parkinsonism.

Definition

An semisynthetic ergotamine alkaloid derivative and powerful dopamine D2 agonist. It inhibits prolactin secretion and release from the pituitary and retards tumor growth.

Weltgesundheitsorganisation (WHO)

Bromocriptine, a semisynthetic ergot alkaloid derivative and prolactin inhibitor was introduced into medicine in 1976. It is used in the prevention of lactation, but because of the risk of rebound effect and since only 10% of women benefit therapeutically from such intervention, the United States Food and Drug Administration has requested manufacturers to no longer indicate preparations containing bromocriptine for this purpose. The World Health Organization is not aware of similar action having been taken elsewhere.

Hazard

Poison; teratogen; developmental abnor- malities of the respiratory system,musculoskeletal system, rogenital system, craniofacial area, and body wall; teratogen; mutagen; questionable car- cinogen; tumorigen; causes nausea, vomiting, orthostatic hypotension; constipation, dyskinesias, psychoses, digital spasm, erythromelalgia.

Mechanism of action

Bromocriptine is absorbed after oral administration, but approximately 90% of a dose undergoes extensive first-pass hepatic metabolism, with the remainder hydrolyzed in the liver to inactive metabolites that are eliminated mostly in the bile. The half-life is relatively short (~3 hours).

Clinical Use

Bromocriptine is an ergot peptide derivative that is a partial agonist at D1-type and a full agonist at D2-type postsynaptic dopamine receptors, usually given in combination with levodopa therapy. It was the first direct dopamine receptor agonist used in treatment of Parkinson's disease after its development as an inhibitor of prolactin release (via activation of anterior pituitary D2 receptors). At low doses (typically 1–5 mg/day), bromocriptine is an effective prolactin inhibitor, and at higher doses (typically 10–20 mg/day), the antiparkinsonism and mood-elevating effects of bromocriptine become apparent.

Nebenwirkungen

Bromocriptine has a number of undesirable side effects, even causing mental disturbances in long-term use.

Bromocriptin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Bromocriptin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 67)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5993 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328
sales03@chemcn.cn China 951 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com China 2531 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
Xi'an MC Biotech, Co., Ltd.
029-89275612 +8618991951683
mcbio_sales@163.com China 2255 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29067 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com CHINA 52867 58
Hangzhou Huarong Pharm Co., Ltd.
571-86758373 +8613588754946
sales@huarongpharm.com CHINA 3149 58
LEAP CHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 24738 58

25614-03-3(Bromocriptin)Verwandte Suche:


  • (5’-alpha)-ropyl)
  • ,6’,18-trione
  • 2-bromo-12’-hydroxy-2’-(1-methylethyl)-5’-alpha-(2-methylpropyl)ergotamin-3’
  • 2-bromo-alpha-ergocryptine
  • 2-bromo-alpha-ergokryptin
  • 2-bromo-alpha-ergokryptine
  • 2-bromoergocryptine
  • alpha-bromoergocriptine
  • bromergocryptine
  • bromocriptin
  • bromoergocriptine
  • ergotaman-3’,6’,18-trione,2-bromo-12’-hydroxy-2’-(1-methylethyl)-5’-(2-methylp
  • (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione
  • Kripton
  • BROMOCRIPTINE
  • Bromoergocryptine mesylate
  • 2-Bromo-α-ergokryptine
  • bromocripitine
  • Ergocryptine, 2-bromo- (8CI)
  • 2-Bromo-α-ergokryptin
  • ErgotaMan-3',6',18-trione,2-broMo-12'-hydroxy-2'-(1-Methylethyl)-5'-(2-Methylpropyl)-, (5'a)-
  • (5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-ergotaman-3',6',18-trione
  • Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'α)-
  • SAN 15-754
  • Sandoz 15-754
  • Bromocriptine\n\nDiscontinued, B682600
  • BromocriptineQ: What is Bromocriptine Q: What is the CAS Number of Bromocriptine Q: What is the storage condition of Bromocriptine Q: What are the applications of Bromocriptine
  • Bromocriptine USP/EP/BP
  • 2-bromo-ergocryptin
  • bromocryptine
  • bromoergocryptine
  • Parlodel
  • BROMOCRITINE
  • 25614-03-3
  • 25614-03-2
  • C32H40BrN5O5
  • Organics
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