Avatrombopag

Avatrombopag Struktur
570406-98-3
CAS-Nr.
570406-98-3
Englisch Name:
Avatrombopag
Synonyma:
Avatrombopag Base,Avatrombopag;AKR-501;Crenolanib Besylate;Avatrombopag (AKR-501);YM477;E 5501;AS 1670542;AVATROMBOPAG;AKR-501 USP/EP/BP;Avatrombopag Crude
CBNumber:
CB72522099
Summenformel:
C29H34Cl2N6O3S2
Molgewicht:
649.65
MOL-Datei:
570406-98-3.mol

Avatrombopag Eigenschaften

Dichte
1.440
Löslichkeit
DMSO:27.33(Max Conc. mg/mL);42.07(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
3.04±0.70(Predicted)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H314 Verursacht schwere Verätzungen der Haut und schwere Augenschäden. Ätzwirkung auf die Haut Kategorie 1B Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P310 Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.

Avatrombopag Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Avatrombopag is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure.It was the third thrombopoietin receptor agonist approved for the treatment of immune thrombocytopenia and the first approved to treat periprocedural thrombocytopenia in patients with chronic liver disease (thereby providing an alternative to blood transfusions for these patients). Avatrombopag was approved for medical use in the United States in 2018, and in the European Union in 2019.

Verwenden

Avatrombopag is used to treat thrombocytopenia (a low number of platelets [type of blood cell needed for blood clotting]) in people with chronic (ongoing) liver disease. It is also used to treat thrombocytopenia in people with chronic immune thrombocytopenia (ITP; an ongoing condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood).

target

TPO receptor

Avatrombopag Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Avatrombopag Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 116)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zison Pharmaceutical (Shandong) Co., Ltd.
+86-0086-531-88259693 +86-18660188356
maguanglei@zisonpharm.com China 57 58
Shandong Risen-Sun Pharmaceutical Co., Ltd
+86-15552509998 +86-15621883869
liutf@jewim.com.cn China 251 58
Jiangsu shring Biopharma Co., Ltd.
+8613372282299
sales@shringchem.com China 3545 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com China 2141 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49391 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 27644 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10523 58
Jinan Ande Pharmaceutical Co.,Ltd.
+8613256107535
andepharm@163.com CHINA 221 58

570406-98-3()Verwandte Suche:


  • AVATROMBOPAG
  • AS 1670542
  • E 5501
  • 4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-
  • Avatrombopag(AS1670542)
  • 1-(3-Chloro-5-{[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidinecarboxylic acid
  • 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbo
  • 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-4-piperidinecarboxylic acid
  • 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]-2-pyridyl]piperidine-4-carboxylic acid
  • AKR-501; YM477; E5501; AS 1670542
  • YM477
  • AKR-501 USP/EP/BP
  • 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2
  • Crenolanib Besylate
  • AKR-501
  • Avatrombopag (AKR-501)
  • Avatrombopag Base,Avatrombopag
  • 4- (2- (6- (4-carboxypyridine-1-yl) - (5-chloronicotinamide) -4- (4-chlorothienyl-2-yl) thiazol-5-yl) -1-cyclohexylpiperazine
  • 1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid (Avatrombopag Impurity)
  • 1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
  • Avatrombopag Monomer
  • Avatrombopag Crude
  • 570406-98-3
  • C29H34Cl2N6O3S2
  • Intermediate
  • API
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