AHU-377 (heMicalciuM salt)
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- CAS-Nr.
- 1369773-39-6
- Englisch Name:
- AHU-377 (heMicalciuM salt)
- Synonyma:
- Sacubitril Calcium;Sacubitril hemicalcium;Sacubitril calcium salt;(alphar;LCZ696-1;AHU377 Calcium Salt;AHU-377 Hemicalcium;Sacubitrial Calcium;LCZ696 Impurity 534-06;SACUBITRIL-13C4 CALCIUM
- CBNumber:
- CB72685916
- Summenformel:
- C48H56CaN2O10
- Molgewicht:
- 861.04364
- MOL-Datei:
- 1369773-39-6.mol
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AHU-377 (heMicalciuM salt) Eigenschaften
- Schmelzpunkt:
- >140°C (dec.)
- Dichte
- 1.24g/cm3 at 20℃
- Dampfdruck
- 0.001Pa at 20℃
- storage temp.
- -20°C
- Löslichkeit
- DMSO (Slightly, Heated), Methanol (Slightly)
- Aggregatzustand
- powder
- Farbe
- white to beige
- LogP
- -0.66-2.9 at 20℃ and pH2-7
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| RIDADR |
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gewässergefährdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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AHU-377 (heMicalciuM salt) Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
Biochem/physiol Actions
Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.
AHU-377 (heMicalciuM salt) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
AHU-377 (heMicalciuM salt) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 279)Lieferanten
- AHU-377 (heMicalciuM salt)
- (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)
- (2S,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester,calcium salt(2:1)
- AHU-377 hemicalcium salt (2:1)
- Calciumbis(4-{[(1S,3R)-1-([1,1'-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl] amino} -4-oxobutanoate)
- Sacubitril Hemicalcium salt
- (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
- [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-
- (alphaR, gammaS) -gamma-[(3- carbonyl, -1-, oxo propyl), amino]-alpha-, biphenyl, -4-, ethyl valerate, calcium salt
- LCZ696(valsartan + sacubitril) impurity 1
- Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
- (alphar
- 1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)
- gammas)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1
- LCZ696-1
- monocalciummono(4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy- 4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate)
- Calcium4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
- (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) (AHU-377 hemicalcium salt)
- AHU377 Calcium Salt
- AHU-377 Hemicalcium
- LCZ696 Impurity 534-06
- (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoicacid4-ethylestercalciumsal
- LCZ696 intermediates，AHU-377 (heMicalciuM salt)
- (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-m...
- SACUBITRIL-13C4 CALCIUM
- Sacubitril-d5 Calcium Salt
- Sacubitril 13C4 CalciumQ: What is
Sacubitril 13C4 Calcium Q: What is the CAS Number of
Sacubitril 13C4 Calcium
- (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
- Sacubitril Calcium
- Sacubitril calcium salt
- Sacubitril hemicalcium
- LCZ-696 Impurity 29 calcium salt
- Ethyl (2R,4S)-5-(Biphenyl-4-yl)-4-(amino)-5-(3-carboxypropionyl)amino]-2-methylpentanoate, calcium salt
- Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
- Calcium 4-((2S,4R)-1-(biphenyl-4-yl) -5-ethoxy-4-methyl-5-oxopentan-2-ylamino)-4-oxobutanoate
- Sacubitril calcium salt（AHU-377 ）
- Sacubitril Calcium Salt CRS
- Sacubitrol calcium salt
- (2R, 4S) -5- (biphenyl-4-yl) -4- (amino) -5- (3-carboxy-propionylamino-2-methyl-ventrate ethyl ester calcium salt
- Sacubitrial Calcium
- LCZ 696 hemicalcium salt
- LCZ696 hemicalcium salt
- Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
- (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
- 1369773-39-6
- 2C24H29NO5Ca
- C48H56CaN2O10
- Intermediates
- LCZ 696
- Pharmaceutical Intermediates
- lcz696
- 1369773-39-6
