GSK215

2743427-26-9

CAS-Nr.: 2743427-26-9

Englisch Name:: GSK215

Synonyma:: GSK215;(2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

CBNumber:: CB810705803

Summenformel:: C50H59F3N10O6S

Molgewicht:: 985.14

MOL-Datei:: 2743427-26-9.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 33

GSK215 Eigenschaften

Siedepunkt:: 1103.2±65.0 °C(Predicted)

Dichte: 1.317±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: DMSO : 250 mg/mL (253.77 mM; Need ultrasonic)

pka: 13.97±0.40(Predicted)

InChIKey: ZGSWGXNEXAXEGV-VSAGVCMVNA-N

Sicherheit

GSK215 Chemische Eigenschaften,Einsatz,Produktion Methoden

in vitro

GSK215 (0.1-1000 nM; 2 h) effectively increases the FAK degradation by >90% and determines a DC50 of 1.3 nM in A549 cells. Its induced degradation is proteasome and ubiquitin-dependent. GSK215 (above 100 nM, 6h) primarily reduces kinases CDK7, RPS6KA3, MET, and GAK. This compound (100 nM, 48 h) inhibits migration, invasion, and collagen deposition in A549 cells.

GSK215 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

GSK215 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 33)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hubei Chuchang Biotech Co., Ltd.	+86-18727130788 +86-18727130788	info@chuchangbiotech.com	China	102	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4691	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4182	55
ShangHai Angti Biotechnology Co., Ltd.	13764913901	info@angtibio.com	China	4740	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8015	62
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2985	58

GSK215
(2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
2743427-26-9
C50H59F3N10O6S