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1311136-84-1

CAS-Nr.: 1311136-84-1

Englisch Name:: N/aa

Synonyma:: (5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-, (5R)-;Kv3.1b,corticolimbic circuits,inhibit,AUT 1,AUT1,dysfunction,Potassium Channel,recombinant human Kv3 channels,human recombinant,KcsA,schizophrenia,Inhibitor,AUT-1,Kv3.2a

CBNumber:: CB84804783

Summenformel:: C18H19N3O4

Molgewicht:: 341.36

MOL-Datei:: 1311136-84-1.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 43

N/aa Eigenschaften

storage temp.: Store at -20°C

Löslichkeit: DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.59(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);87.88(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);14.65(Max Conc. mM)

Aggregatzustand: A crystalline solid

Sicherheit

N/aa Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

AUT1 is a positive modulator of the voltage-gated potassium channel subtypes K_v3.1b, K_v3.2a, and K_v3.3 (EC₅₀s = 4.7, 4.9, and 31.6 μM, respectively, in a patch-clamp assay). It is selective for K_v3.1b, K_v3.2a, and K_v3.3 over K_v1.5 and K_v7.1/minK channels but also inhibits the serotonin (5-HT) transporter, 5-HT₃ receptor, and α1 subunit-containing nicotinic acetylcholine receptor (nAChR) in a panel of 26 ion channels, receptors, and transporters. AUT1 increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices when used at concentrations of 1 and 10 μM.

Verwenden

(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione, is a novel modulator of Kv3 potassium channels which biological studies have shown it regulates the firing of parvalbumin-positive cortical interneurons.

N/aa Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N/aa Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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2,4-Imidazolidinedione, 5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-, (5R)-
(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
Kv3.1b,corticolimbic circuits,inhibit,AUT 1,AUT1,dysfunction,Potassium Channel,recombinant human Kv3 channels,human recombinant,KcsA,schizophrenia,Inhibitor,AUT-1,Kv3.2a
1311136-84-1